{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:15:28Z","timestamp":1761992128649,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lesion length has been an important factor in predicting a worse outcome after percutaneous coronary interventions (PCI); however, the safety and efficacy of second\u2010generation drug eluting stents in very long coronary lesions has not been validated in large scale randomized controlled trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a patient level pooled analysis of 13,266 patients undergoing planned overlapping stent treatment of very long coronary lesions with the XIENCE V everolimus eluting coronary stent system from 6 trials evaluating the XIENCE V stent (Spirit II, III, IV, V, Spirit Small Vessel and XIENCE V USA). Patients were divided into two cohorts, a very long lesion (VLL) group (lesions \u226535 mm) and a control group (lesions &gt;24 to &lt;35 mm). The primary outcome measures were Target Lesion Failure (TLF), Major Adverse Cardiac Events (MACE), and Academic Research Consortium (ARC) defined definite and probable stent thrombosis at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13,266 patients were included in the pooled analysis of which 2.4% (323 patients with 328 total lesions) had a mean lesion length of 47.1\u2009\u00b1\u200913.7 mm in the VLL group which were compared to controls comprised of 3.6% of the cohort (482 patients with 500 total lesions) with mean lesion length of 28.1\u2009\u00b1\u20092.4 mm.There was no significant difference in the rates of TLF between the VVL and control groups (8.9 vs. 10%, <jats:italic>P<\/jats:italic>\u2009=\u20090.63), MACE (9.2 vs. 10%, <jats:italic>P<\/jats:italic>\u2009=\u20090.74) or stent thrombosis (1.6 vs. 1.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.92) at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the treatment of very long coronary lesions, the XIENCE V stent appears as safe and effective as percutaneous coronary interventions for long lesions. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26711","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T12:18:03Z","timestamp":1471868283000},"page":"984-991","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes after PCI treatment of very long lesions with the XIENCE V everolimus eluting stent; Pooled analysis from the SPIRIT and XIENCE V USA prospective multicenter trials"],"prefix":"10.1002","volume":"89","author":[{"given":"Georgios","family":"Bouras","sequence":"first","affiliation":[{"name":"Yale Cardiovascular Research Group, Yale University Medical Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny","family":"Jhamnani","sequence":"additional","affiliation":[{"name":"Yale Cardiovascular Research Group, Yale University Medical Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian G.","family":"Ng","sequence":"additional","affiliation":[{"name":"Yale Cardiovascular Research Group, Yale University Medical Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido","family":"Haimi","sequence":"additional","affiliation":[{"name":"Yale Cardiovascular Research Group, Yale University Medical Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Mao","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Deible","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry","family":"Cao","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnankutty","family":"Sudhir","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-7497","authenticated-orcid":false,"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"Yale Cardiovascular Research Group, Yale University Medical Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.3.497"},{"key":"e_1_2_7_3_1","first-page":"529","article-title":"A report of the American College of Cardiology\/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee on Percutaneous Transluminal Coronary Angioplasty)","volume":"12","author":"[Anonymous]. 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