{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:52:48Z","timestamp":1779195168064,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bristol-Myers Squibb and Sanofi-Aventis (to PARIS study)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (PPI) may decrease the availability of clopidogrel by competitive antagonism, leading to a potential increase in ischemic events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated patients from the all\u2010comer PARIS registry treated with dual antiplatelet therapy (DAPT) with aspirin and clopidogrel following coronary stenting for outcomes stratified by PPI use. Two\u2010year major adverse cardiovascular events (MACE), composite of cardiac death, myocardial infarction, definite or probable stent thrombosis or target lesion revascularization (TLR), and net adverse cardiac events (NACE), composite of MACE or Bleeding Academic Research consortium (BARC) type 3 or 5 bleeding were assessed. We also explored associations between PPI use and patterns of 2\u2010year DAPT cessation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised 4635 patients (23% PPI users) with mean age 64.4 \u00b111.4 years. Two year adjusted risk of MACE (HR: 1.27, 95% CI: 1.04\u20131.55), NACE (HR: 1.21, 95% CI: 1.01\u20131.44) and TLR (HR: 1.33, 95% CI: 1.04\u20131.71) were significantly higher in PPI users vs. non\u2010users, without a difference in bleeding. Although the incidence of 2\u2010year DAPT discontinuation and interruption was similar, DAPT disruption was significantly lower among PPI users vs. non\u2010users (10.0% vs. 14.7%, <jats:italic>P<\/jats:italic> &lt;0.0001). Compared to non\u2010PPI users on continued DAPT, disruption was associated with higher MACE in both PPI users (HR: 2.34, 95% CI: 1.38\u20133.97) and non\u2010users (HR: 1.41, 95% CI: 1.02\u20131.94) but greater BARC 3,5 bleeding only in non\u2010PPI users (HR: 2.06, 95% CI: 1.21\u20133.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In clopidogrel treated PCI patients, the 2\u2010year adjusted risk of MACE and NACE was significantly higher in PPI users driven by higher TLR compared to non\u2010PPI users, without a difference in bleeding. PPI use was associated with lower incidence of DAPT disruption without an increase in disruption related bleeding compared to non\u2010PPI users on DAPT. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26716","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T09:36:49Z","timestamp":1474450609000},"source":"Crossref","is-referenced-by-count":12,"title":["Impact of proton pump inhibitors and dual antiplatelet therapy cessation on outcomes following percutaneous coronary intervention: Results From the PARIS Registry"],"prefix":"10.1002","volume":"89","author":[{"given":"Jaya","family":"Chandrasekhar","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Bansilal","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai New York New 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