{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:51:51Z","timestamp":1788580311602,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe long\u2010term risk of mortality, aortic insufficiency (AI), and re\u2010intervention following balloon aortic valvuloplasty (BAV) in pediatric patients and to identify risk factors for re\u2010intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies report long\u2010term outcomes following BAV in infants and children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Kaplan\u2010Meier estimates and proportional hazards regression were used in a retrospective study of 154 patients undergoing BAV from 1993 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010six (49%) patients were neonates. Aortic stenosis (AS) gradients were reduced by 38\u2009\u00b1\u200919 mm Hg. Moderate or severe AI developed acutely in 19 (12%) patients. Estimates of fifteen\u2010year transplant\u2010free survival were 85% (95%CI: 73\u201392%) in neonates, 94% (95%CI: 80\u201396%) in infants, and 100% in older patients. Neonates had an elevated long\u2010term risk of AI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and left heart re\u2010interventions (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). At 15 years, an estimated 32% (95%CI: 15\u201350%) of neonates and 44% (95%CI: 20\u201365%) of non\u2010neonates remained free from re\u2010intervention; an estimated 45% (95% CI: 26\u201363%) of neonates and 62% (95% CI: 40\u201377%) of non\u2010neonates remained free of aortic valve replacement (AVR). Neonatal age, additional left heart lesions, higher pre\u2010 and post\u2010dilation gradients, and acute AI were associated with LVOT re\u2010interventions. Post\u2010dilation gradient \u226530 mm Hg and acute AI were associated with AVR. Patients with moderate or severe acute AI but a residual AS gradient &lt;30 mm Hg had a greater risk of AVR compared to patients with a residual AS gradient \u226530 mm Hg but mild or less AI (HR: 2.98 [95% CI: 1.01\u20138.77]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While post\u2010BAV survival is excellent, long\u2010term risks of AI and re\u2010intervention are significant. Acute AI is a more strongly associated with AVR than residual AS. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26722","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T09:36:44Z","timestamp":1474450604000},"page":"288-296","source":"Crossref","is-referenced-by-count":30,"title":["Long\u2010term outcomes and re\u2010interventions following balloon aortic valvuloplasty in pediatric patients with congenital aortic stenosis: A single\u2010center study"],"prefix":"10.1002","volume":"89","author":[{"given":"Patrick M.","family":"Sullivan","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital Los Angeles, University of Southern California Keck School of Medicine Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin E.","family":"Rubio","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Seattle Children's 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