{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:11:24Z","timestamp":1740103884688,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p><jats:styled-content>Objectives:<\/jats:styled-content> We sought to determine the effects of experience on the Mitraclip<jats:sup>\u00ae<\/jats:sup> procedure steps as well as procedure safety and functional results.<\/jats:p><jats:p><jats:styled-content>Background:<\/jats:styled-content> MR has proven deleterious in heart failure. Mitraclip<jats:sup>\u00ae<\/jats:sup> therapy evolved an important option in patients with severely reduced left ventricular function (LVEF).<\/jats:p><jats:p><jats:styled-content>Methods:<\/jats:styled-content> Between 2011 and 2016, 126 consecutive patients were grouped in three groups and investigated in a prospective observational study. We evaluated the duration of procedural steps, safety endpoints, and functional results.<\/jats:p><jats:p><jats:styled-content>Results:<\/jats:styled-content> The median logistic EuroScore was 32% (7\u201340%). Ninety\u2010five percent of patients were in NYHA\u2010stage \u2265III and 51% had a LVEF &lt;30%. Groups were homogeneous as to their baseline NYHA status and right heart catheterization data. Echocardiography data are comparable, albeit with a decreasing effective regurgitant orifice area (0.44\u2009\u00b1\u20090.21 group I vs. 0.34\u2009\u00b1\u20090.22 group III, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Frailty was less frequent and baseline 6 min walking test results improved from group I to group III. Duration of a first clip placement decreased from 106\u2009\u00b1\u200950 to 50\u2009\u00b1\u200921 min (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Total procedure time decreased from 221\u2009\u00b1\u200970 to 144\u2009\u00b1\u200968 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The number of clips implanted increased from 66 to 79 (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). MitraClip<jats:sup>\u00ae<\/jats:sup> implantation was effective in either group but the combined safety endpoint was reached less frequent in group III (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). There was no difference in MACCE rate, 30 day\u2010 or intrahospital\u2010mortality between groups.<\/jats:p><jats:p><jats:styled-content>Conclusion:<\/jats:styled-content> Safety and duration of procedure steps improved substantially with experience. MR reduction was sustained from the beginning without further improvement. Patient selection is a key factor for success. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.26806","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T09:36:49Z","timestamp":1474450609000},"page":"313-320","source":"Crossref","is-referenced-by-count":4,"title":["Influence of experience on procedure steps, safety, and functional results in edge to edge mitral valve repair\u2014a single center study"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-5842","authenticated-orcid":false,"given":"Karsten","family":"Hamm","sequence":"first","affiliation":[{"name":"Department of Cardiology Cardiovascular Center Bad Neustadt Bad Neustadt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zacher","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cardiovascular Center Bad Neustadt Bad Neustadt 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