{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:18:18Z","timestamp":1761844698741},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T00:00:00Z","timestamp":1474675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p><jats:styled-content>Background:<\/jats:styled-content> Postoperative state is characterized by increased thrombotic risk by virtue of platelet activation. Whether aspirin ameliorates this risk in patients with established coronary artery disease undergoing cardiac or noncardiac surgery is unknown. We conducted a systematic review and meta\u2010analysis to compare the risk of major adverse cardiac events (MACE) and the risk of bleeding in patients with early (3\u20135 or more days before surgery) vs. late discontinuation(&lt;3\u20135 days)\/no discontinuation of aspirin.<\/jats:p><jats:p><jats:styled-content>Methods:<\/jats:styled-content> Multiple databases were searched from inception of these databases until March 2015 to identify studies that reported discontinuation of aspirin in patients undergoing surgery. The outcomes measured were all cause mortality, nonfatal myocardial infarction and other relevant thrombotic events (MACE) which also may include, fatal and nonfatal MI, stent thrombosis and restenosis, stroke, perioperative cardiovascular complications (heart failure, MI, VTE, acute stroke) and perioperative bleeding during the perioperative period to up to 30 days after surgery.<\/jats:p><jats:p><jats:styled-content>Results:<\/jats:styled-content> A total of 1,018 titles were screened, after which six observational studies met the inclusion criteria. Our analysis suggests that there is no difference in MACE with planned discontinuation of aspirin (OR\u2009=\u20091.17, 95% CI\u2009=\u20090.76\u20131.81; <jats:italic>P<\/jats:italic>\u2009=\u20090.05; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200955%). Early discontinuation of aspirin showed a decreased risk of peri\u2010operative bleeding (OR 0.82, 95% CI\u2009=\u20090.67\u20130.99; <jats:italic>P<\/jats:italic>\u2009=\u20090.04; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200942%).<\/jats:p><jats:p><jats:styled-content>Conclusion:<\/jats:styled-content> Our analysis suggests that planned short\u2010term discontinuation in the appropriate clinical setting appears to be safe in the correct clinical setting with no increased risk of thrombotic events and with a decreased risk of bleeding. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.26807","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T08:36:46Z","timestamp":1474706206000},"page":"1168-1175","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcomes associated with per\u2010operative discontinuation of aspirin in patients with coronary artery disease: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"89","author":[{"given":"Faraz Khan","family":"Luni","sequence":"first","affiliation":[{"name":"Mercy Saint Vincent Medical Center Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris","family":"Riaz","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdur Rahman","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Louisville Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talha","family":"Riaz","sequence":"additional","affiliation":[{"name":"Bronx Lebanon Hospital New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Husnain","sequence":"additional","affiliation":[{"name":"University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[{"name":"University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Taleb","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Kanjwal","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Toledo Medical Center Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadik A.","family":"Khuder","sequence":"additional","affiliation":[{"name":"University of Toledo Medical Center Toledo Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60503-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92808-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.jacc.2006.04.026","article-title":"AHA\/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the national heart, lung, and blood institute","volume":"47","author":"Smith SC","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm316"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_8_10_1","unstructured":"Higgins JPT Green S editors. 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