{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:41:49Z","timestamp":1789897309014,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the incidence and predictors of permanent pacemaker (PPM) requirement following transcatheter aortic valve replacement (TAVR) with the mechanically expanded Lotus<jats:sup>TM<\/jats:sup> Valve System (Boston Scientific).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Pacemaker implantation is the most common complication following TAVR. Predictors of pacing following TAVR with the Lotus valve have not been systematically assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with severe aortic stenosis who underwent Lotus valve implantation were prospectively recruited at a single\u2010centre. Patients with a pre\u2010existing PPM were excluded. Baseline ECG, echocardiographic and multiple detector computed tomography as well as procedural telemetry and depth of implantation were independently analyzed in a blinded manner. The primary endpoint was 30\u2010day incidence of pacemaker requirement (PPM implantation or death while pacing\u2010dependent). Multivariate analysis was performed to identify independent predictors of the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 104 consecutive patients underwent TAVR with the Lotus valve with 9\/104 (9%) with a pre\u2010existing PPM excluded. New or worsened procedural LBBB occurred in 78%. Thirty\u2010day incidence of the primary pacing endpoint was 28%. The most common indication for PPM implantation was complete heart block (CHB) (69%). Independent predictors of the primary endpoint included pre\u2010existing RBBB (hazard ratio [HR] 2.8, 95% CI 1.1\u20137.0; <jats:italic>P<\/jats:italic>\u2009=\u20090.032) and depth of implantation below the noncoronary cusp (NCC) (HR 2.4, 95% CI 1.0\u20135.7; <jats:italic>P<\/jats:italic>\u2009=\u20090.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Almost a third of Lotus valve recipients require pacemaker implantation within 30 days. The presence of pre\u2010existing RBBB and the depth of prosthesis implantation below the NCC were significant pacing predictors. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26857","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T16:04:07Z","timestamp":1479312247000},"page":"147-154","source":"Crossref","is-referenced-by-count":22,"title":["Incidence and predictors of permanent pacemaker implantation following treatment with the repositionable Lotus\u2122 transcatheter aortic valve"],"prefix":"10.1002","volume":"90","author":[{"given":"Sarah","family":"Zaman","sequence":"first","affiliation":[{"name":"Monash Cardiovascular Research Centre, Department of Medicine (Monash Medical Centre), School of Clinical Sciences Monash University"},{"name":"Cardiovascular Division Monash Heart, Monash Medical Centre Melbourne Victoria 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