{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:22Z","timestamp":1762867042600},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Degenerated surgical mitral valve repairs or surgical prostheses are currently being treated with transcatheter mitral valve replacement (TMVR). We report the procedural and mid\u2010term assessment of thirteen cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 12\/2013 to 12\/2015, 13 consecutive patients with degenerated mitral valve repair or valve replacement were treated. Patients were assessed for mitral valve academic valve consortium (MVARC) defined outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immediate procedural MVARC defined technical success was 92%. At 30\u00a0days MVARC device and procedure success were 61% and 84%, respectively. Mean follow\u2010up was 150\u00a0days [IQR 40\u2013123\u00a0days]. There were 2 late major adverse outcomes, a noncardiac related death (628\u00a0days) and a stroke (382\u00a0days). The mean mitral gradient decreased from 9.5\u00a0\u00b1\u00a03.4 to 5.5\u00a0\u00b1\u00a02.6\u00a0mm\u00a0Hg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Three patients were found to have high gradients, two presented with heart failure while another patient was found to have reduced leaflet motion and abnormal thickening postprocedure. The two patients with heart failure were treated with enoxaparin, which caused subsequent resolution of increased valve gradients in one patient. The other patient could not tolerate prolonged treatment from anticoagulation due to gastrointestinal bleeding. Three of 13 patients were treated with dual\u2010antiplatelet therapy and were suspected to have valve thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thrombotic related dysfunction post\u2010TMVR occurred in 15% (2\/13) of patients and one patient had abnormal leaflet thickening that may have been thrombus related. Dual\u2010antiplatelet therapy was used in all 3 cases suggesting the possible need for oral anticoagulation postmitral valve\u2010in\u2010valve therapy. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26909","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T06:12:50Z","timestamp":1486707170000},"page":"321-328","source":"Crossref","is-referenced-by-count":12,"title":["Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures"],"prefix":"10.1002","volume":"90","author":[{"given":"Marvin H.","family":"Eng","sequence":"first","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee Dee","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"DNP","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heider","family":"Arjomand","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Nemeh","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Henry Ford Health System Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Paone","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Henry Ford Health System Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Cardiac Structural Interventions, NorthShore University Health System Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Medicine Henry Ford Health System, Center for Structural Heart Disease Detroit 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