{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:48:57Z","timestamp":1762098537239,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report procedural and 30\u2010day clinical outcomes following transcatheter aortic valve replacement (TAVR) with Lotus Valve system in a high\u2010risk population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Lotus valve is a second\u2010generation TAVR fully repositionable and retrievable device. RELEVANT (REgistry of Lotus valvE for treatment of aortic VAlve steNosis with Tavr) study is an Italian prospective multicentre registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five major centers performing TAVR using Lotus participated. All high\u2010risk symptomatic patients with severe aortic stenosis were evaluated by a heart team and screened for eligibility for TAVR. Primary end\u2010points were procedural and 30\u2010day mortality. Secondary endpoints included procedural and 30\u2010day safety\/effectiveness metrics according to Valve Academic Research Consortium (VARC)\u22122 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and twenty\u2010five patients undergoing TAVR with Lotus were enrolled. Mean age was 82.6\u2009\u00b1\u20096.3 years, 51.6% females. Mean STS score for mortality was 8.3\u2009\u00b1\u20095.6. Procedural success was achieved in 98.7% of patients. All\u2010cause mortality was 2.2% at discharge and 2.7% at 30\u2010day. Stroke rate was 2.2% at discharge and 3.1% at 30\u2010day. Patients requiring a new permanent pacemaker implantation were 30.7% at discharge and 31.8% at 30\u2010day. Paravalvular regurgitation (PVR) was trace\/mild in 99.1% of patients at discharge. Only two patients (0.9%) had moderate PVR at discharge and at 30\u2010day, whereas none had severe PVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RELEVANT study showed that TAVR using Lotus, in a real\u2010world population of patients with severe aortic stenosis at high surgical risk, was associated with excellent device success implantation and early safety according to VARC\u20102 definition. The pacemaker implantation rate was about a third of patients. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26914","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T05:48:21Z","timestamp":1485928101000},"page":"1206-1211","source":"Crossref","is-referenced-by-count":8,"title":["Procedural and 30\u2010day clinical outcomes following transcatheter aortic valve replacement with lotus valve: Results of the RELEVANT study"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6439-1018","authenticated-orcid":false,"given":"Rocco A.","family":"Montone","sequence":"first","affiliation":[{"name":"Interventional Cardiology, IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Testa","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fraccaro","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Castriota","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Maria Cecilia Hospital, GVM care &amp; research Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Nerla","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Maria Cecilia Hospital, GVM care &amp; research Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Angelillis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale Cisanello, University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Tusa","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Cardiology IRCCS Ospedale San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Garatti","sequence":"additional","affiliation":[{"name":"IRCCS Policlinico San Donato Cardiac Surgery Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Sonia","family":"Petronio","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale Cisanello, University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedy","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8SQA12"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht381"},{"key":"e_1_2_6_10_1","unstructured":"FalkV.The RESPOND study: Safety and efficacy of a fully repositionable and retrievable aortic valve used in routine clinical practice. In: EuroPCR 2016 Paris 2016."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.067"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.06.042"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.12.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.540"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3316"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.927152"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11SWA30"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.003"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:05:24Z","timestamp":1695996324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ccd.26914"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26914","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}