{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:22:18Z","timestamp":1779250938086,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to study whether the level of completeness of revascularization as measured by the SYNTAX revascularization index (SRI) independently predicts adverse ischemic events after percutaneous coronary intervention (PCI) with second\u2010generation drug\u2010eluting stents (DES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The SRI quantifies the proportion of revascularized myocardium. It has been shown to independently predict adverse ischemic events after PCI with first\u2010generation DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 1,900 patients enrolled in a registry to evaluate safety and effectiveness of everolimus drug\u2010eluting stent (SEEDS) for coronary revascularization, the SRI was calculated and available for 1,851 patients. The patients were stratified into three groups according to the degree of revascularization (SRI\u2009=\u2009100% [complete revascularization], SRI\u2009=\u200950 to &lt;100%, and SRI &lt;50%). Two\u2010year mortality and major adverse cardiac events (MACE) were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SRI ranged from 4\u2013100%, with a mean of 85.4%. Complete revascularization was achieved in 1,190 patients, while the SRI was 50% to &lt;100% in 472 patients and &lt;50% in 189 patients. Two\u2010year mortality and MACE rates were higher in patients with lower SRI. ROC analysis showed an optimal SRI cutoff of 85% for predicting the 2\u2010year mortality risk. An SRI \u226585% was associated with a similar risk of death to complete revascularization. The SRI independently predicted 2\u2010year mortality and MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SRI predicts mortality and adverse ischemic events in patients with complex CAD who underwent contemporary PCI with second\u2010generation DES. Revascularizing \u226585% of the CAD burden was associated with a good prognosis and should be considered as a reasonable goal. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26916","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T07:32:58Z","timestamp":1484983978000},"page":"541-548","source":"Crossref","is-referenced-by-count":5,"title":["Impact of completeness of revascularization in complex coronary artery disease as measured with the SYNTAX revascularization index: An SEEDS Substudy"],"prefix":"10.1002","volume":"89","author":[{"given":"Bo","family":"Xu","sequence":"first","affiliation":[{"name":"Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation New York New York"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changdong","family":"Guan","sequence":"additional","affiliation":[{"name":"Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejin","family":"Yang","sequence":"additional","affiliation":[{"name":"Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Cardiovascular Institute Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Han","sequence":"additional","affiliation":[{"name":"General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Su","sequence":"additional","affiliation":[{"name":"Wuhan Asia Heart Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuyi","family":"Yuan","sequence":"additional","affiliation":[{"name":"The 1st Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation New York New York"},{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Medical Center New York New York"},{"name":"H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Morristown Medical Center Morristown New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.069237"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.031"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.021"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001803"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M10_05"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.03.056"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I1A12"},{"key":"e_1_2_6_13_1","unstructured":"GranthamJA.Patients procedures and patient reported health status: a first report from the OPEN CTO Trial Investigators.2015; 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