{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:45:57Z","timestamp":1757699157362},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Implantation of early\u2010generation metallic drug\u2010eluting stents (DES) in patients with acute myocardial infarction (AMI) is associated with poor vessel wall healing. Use of biodegradable polymer (BP) DES might improve safety outcomes; however, the impact of varying drug elution and polymer absorption kinetics of BP\u2010DES on clinical outcomes in the AMI population is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This subgroup analysis of the randomized PANDA III trial included 732 patients (366 in each group) presenting with recent (&lt;1 month) AMI. Primary endpoint was 1\u2010year target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (MI), or ischemia\u2010driven target lesion revascularization. Secondary endpoints included a patient\u2010oriented composite endpoint (PoCE) of all\u2010cause death, all MI, or any revascularization; individual TLF and PoCE components; and definite\/probable stent thrombosis (ST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between\u2010groups in baseline clinical, angiographic, or procedural characteristics other than the proportion of post\u2010dilatation, which was performed more frequently with the BuMA stent (53.9% vs. 44.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.004). After 1 year, compared to Excel SES implantation in patients with AMI, BuMA was associated with similar incidences of TLF and PoCE (5.5% vs. 8.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.14; 8.8% vs. 9.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.61, respectively) but lower incidences of MI (2.5% vs. 6.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), target vessel MI (2.2% vs. 5.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), and definite\/probable ST (0.3% vs. 2.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BuMA SES, with faster drug elution rate and polymer absorption kinetics, might improve safety outcomes compared to Excel SES in the high\u2010risk AMI population. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26918","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T02:35:23Z","timestamp":1484966123000},"page":"520-527","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of two biodegradable\u2010polymer\u2010based sirolimus\u2010eluting stents with varying elution and absorption kinetics in patients with acute myocardial infarction: A subgroup analysis of the <scp>PANDA<\/scp> III trial"],"prefix":"10.1002","volume":"89","author":[{"given":"Changdong","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaifeng Central Hospital Kaifeng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yunnan St. John's Hospital Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Liaoning Provincial People's Hospital Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dazhou Central Hospital Dazhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runlin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fu Wai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the PANDA III 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