{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:51Z","timestamp":1762867071280},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Association of Percutaneous Cardiovascular Intervention"},{"name":"Veronesi Foundation-Cardiovascular research"},{"name":"Italian Society of Cardiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess whether moderate\u2010to\u2010severe CKD is a treatment modifier for benefit or harm in patients randomly allocated to 24\u2010month versus 6\u2010month DAPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>It is still unclear whether chronic kidney disease CKD should impact on the decision\u2010making on optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>PRODIGY trial randomized 1970 all\u2010comer patients at 24\u2010month versus 6\u2010month DAPT after PCI. Patients with moderate\u2010to\u2010severe CKD (<jats:italic>n<\/jats:italic>\u2009=\u2009604; 30.7%) were older, more likely to be women, to have hypertension, diabetes, prior MI or PCI, with higher severity of coronary artery disease (CAD), but were less frequently smokers or presenting with stable CAD. After adjustment, the 2\u2010year rates of primary endpoint (composite of death, myocardial infarction and cerebrovascular accident), as well as bleeding and net adverse clinical events were higher in patients with moderate\u2010to\u2010severe CKD. DAPT prolongation at 24\u2010month did not reduce the primary endpoint in both CKD (adj. HR: 0.957; 95% CI 0.652\u20131.407; <jats:italic>P<\/jats:italic>\u2009=\u20090.825) and no\u2010CKD (adj. HR: 1.341; 95% CI 0.861\u20132.086; <jats:italic>P<\/jats:italic>\u2009=\u20090.194) groups (Pint\u2009=\u20090.249), but increased bleeding in both groups (CKD: adj. HR: 1.999; 95% CI 1.100\u20133.632; <jats:italic>P<\/jats:italic>\u2009=\u20090.023; no\u2010CKD: adj. HR: 2.880; 95% CI 1.558\u20135.326; <jats:italic>P<\/jats:italic>\u2009=\u20090.001; Pint\u2009=\u20090.407).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderate\u2010to\u2010severe CKD did not modify the effect of a prolonged or shortened DAPT duration in largely unselected patients undergoing stent implantation. Our analysis suggests that CKD should not be a major driver in the decision\u2010making on the duration of DAPT after stent implantation. This exploratory study is underpowered and should be considered hypothesis\u2010generating only. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26921","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:57:10Z","timestamp":1487149030000},"source":"Crossref","is-referenced-by-count":14,"title":["Impact of chronic kidney disease on 2\u2010year clinical outcomes in patients treated with 6\u2010month or 24\u2010month DAPT duration: An analysis from the PRODIGY trial"],"prefix":"10.1002","volume":"90","author":[{"given":"Giuseppe","family":"Gargiulo","sequence":"first","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern Switzerland"},{"name":"Department of Advanced Biomedical Sciences Federico II University of Naples  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern 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