{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:34:22Z","timestamp":1761863662212},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to investigate a new angiographic method for aortic regurgitation (AR) severity assessment in the setting of transcatheter aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>AR after TAVI is common but challenging to quantitate, especially in the cath\u2010lab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 228 patients, AR was quantitated before and after TAVI by echocardiography and by video\u2010densitometric analysis of aortograms. Contrast time\u2013density curves for the aortic root (the reference region) and the left ventricular outflow tract, LVOT were generated. LVOT\u2010AR was calculated as the area under the curve of the LVOT as a fraction of the area under the curve of the reference region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVOT\u2010AR was 0.10\u00a0\u00b1\u00a00.08, 0.13\u00a0\u00b1\u00a00.10 and 0.28\u00a0\u00b1\u00a00.14 in none\u2010trace, mild and moderate\u2010severe post\u2010TAVI AR as defined by echocardiography (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and a cutpoint of &gt;0.17 corresponded to moderate\u2010severe AR on echocardiography (area under the curve\u00a0=\u00a00.84). At follow\u2010up (median, 496 days), patients with LVOT\u2010AR\u2009\u2264\u20090.17 showed a significant reduction of LV mass index (LVMi; 121 [95\u2013148] vs. 140 [112\u2013169]\u00a0g\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) and the prevalence of LV hypertrophy (LVH; 64 vs. 88%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) compared to baseline. In patients with LVOT\u2010AR\u00a0&gt;\u00a00.17, LVMi (149 [121\u2013178] vs. 166 [144\u2013188]\u00a0g\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.14) and the prevalence of LVH (74 vs. 87%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.23) did not show a significant change. Compared to patients with LVOT\u2010AR\u2009\u2264\u20090.17, those with LVOT\u2010AR\u00a0&gt;\u00a00.17 had an increased 30\u2010day (16.4% vs. 7.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035) and one year mortality (32.9 vs. 14.2%, log rank <jats:italic>P<\/jats:italic> value\u00a0=\u00a00.001; HR: 2.690 [1.461\u20134.953], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LVOT\u2010AR\u00a0&gt;\u00a00.17 corresponds to greater than mild AR as defined by echocardiography and predicts impaired LV reverse remodeling and increased early and midterm mortality after TAVI. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26926","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T02:34:02Z","timestamp":1484966042000},"page":"650-659","source":"Crossref","is-referenced-by-count":23,"title":["Angiographic assessment of aortic regurgitation by video\u2010densitometry in the setting of TAVI: Echocardiographic and clinical correlates"],"prefix":"10.1002","volume":"90","author":[{"given":"Mohammad","family":"Abdelghani","sequence":"first","affiliation":[{"name":"Academic Medical Center Amsterdam The Netherlands"},{"name":"Cardiology Department Al\u2010Azhar University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama I. I.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Cardialysis Core Laboratories and Clinical Trial Management Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.","family":"Tijssen","sequence":"additional","affiliation":[{"name":"Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robbert J.","family":"de Winter","sequence":"additional","affiliation":[{"name":"Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jan","family":"Baan","sequence":"additional","affiliation":[{"name":"Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"Thoraxcenter, Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Cardialysis Core Laboratories and Clinical Trial Management Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M.","family":"Campos","sequence":"additional","affiliation":[{"name":"The Heart Institute (InCor), University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"},{"name":"Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio S.","family":"Leite","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande do Sul\/Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Mangione","sequence":"additional","affiliation":[{"name":"Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo S\u00e3o Paulo 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