{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:25:10Z","timestamp":1784672710053,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Ascertaining risk of contrast induced acute kidney injury (CI\u2010AKI) in ST\u2010segment elevation myocardial infarction (STEMI) patients undergoing multi\u2010vessel percutaneous coronary intervention (MV\u2010PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Complete revascularization may improve outcomes in STEMI patients with multi\u2010vessel disease. However, a practice of MV\u2010PCI may be associated with a higher risk of CI\u2010AKI. We aimed to evaluate the risk of CI\u2010AKI in patients with STEMI and MV\u2010PCI and examine the accuracy of a validated risk score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Cochrane Library, EMBASE, EBSCO, Web of Science, and CINAHL databases from inception through August 31, 2016 for randomized studies comparing CI\u2010AKI rates with MV\u2010PCI and infarct\u2010related artery (IRA) only PCI during index hospitalization. A random effects model was used to estimate the risk ratio (RR) and respective 95% confidence intervals (CI). We queried the Nationwide Inpatient Sample (NIS) to assess the ability of the Mehran risk score to accurately predict the incidence of CI\u2010AKI in patients undergoing MV\u2010PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four randomized studies (<jats:italic>N<\/jats:italic>\u2009=\u20091,602) were included in the final analysis. The risk of CI\u2010AKI was low and no difference was observed with MV\u2010PCI (1.45%) compared with IRA\u2010only (1.94%) (RR 0.73, 95% CI 0.34\u20101.57; <jats:italic>P<\/jats:italic>\u2009=\u20090.57). From 2009 to 2012, excluding shock, there were 11,454 MV\u2010PCI for STEMI patients in the NIS. The Mehran risk score accurately discriminated 78% of the patients who developed CI\u2010AKI in this cohort (<jats:italic>c<\/jats:italic>\u2010statistic of 0.78, <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MV\u2010PCI in STEMI is not associated with a higher risk of CI\u2010AKI and the Mehran risk score can identify patients at higher risk for this complication. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26928","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T13:23:12Z","timestamp":1485177792000},"page":"205-212","source":"Crossref","is-referenced-by-count":17,"title":["Risk of contrast\u2010induced acute kidney injury in ST\u2010elevation myocardial infarction patients undergoing multi\u2010vessel intervention\u2010meta\u2010analysis of randomized trials and risk prediction modeling study using observational data"],"prefix":"10.1002","volume":"90","author":[{"given":"Saurav","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Division of Cardiology St. Luke's\u2010Roosevelt Hospital Center of the Mount Sinai Health System New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amartya","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Texas Tech University Health Sciences Center El Paso Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Sardar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Director of Interventional Research, Icahn School of Medicine, Mount Sinai Health System New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyaz","family":"Bashir","sequence":"additional","affiliation":[{"name":"Division of Cardiology Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Giri","sequence":"additional","affiliation":[{"name":"Penn Cardiovascular Outcomes Quality &amp; Evaluative Research Center, Perelman School of Medicine, University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnette D.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Warren Alpert School of Medicine and Brown University Rhode Island Hospital Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.046"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305520"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000336"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70238-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.075"},{"key":"e_1_2_6_7_1","unstructured":"HigginsJPT GreenS(editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration 2011.Available fromwww.cochrane-handbook.org.Accessed January 15 2015."},{"key":"e_1_2_6_8_1","unstructured":"Healthcare Cost and Utilization Project (HCUP). July 2008. Agency for Healthcare Research and Quality Rockville MD; 2008.HCUP Databases.http:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp. Accessed September 1 2015."},{"key":"e_1_2_6_9_1","unstructured":"http:\/\/www.cms.gov\/Medicare\/Coding\/ICD9ProviderDiagnosticCodes\/codes.html. 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