{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:37:24Z","timestamp":1789616244911,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200076"],"award-info":[{"award-number":["81200076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330033"],"award-info":[{"award-number":["81330033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare vascular healing after drug\u2010eluting stent (DES) implantation between plaque rupture (PR) and plaque erosion (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular response after stent implantation in patients with PR has been extensively studied. Little is known about vascular healing after stent implantation in PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five ACS patients who received optical coherence tomography (OCT) imaging of the culprit lesions both before and after stent implantation at baseline as well as at 6 months were included in this study. Patients were divided into two groups: PR (<jats:italic>n<\/jats:italic>\u2009=\u200919) and PE (<jats:italic>n<\/jats:italic>\u2009=\u200924). Prestent thrombus burden and poststent intrastent structure (ISS) volume were analyzed during the index procedure. The ratio of uncovered to total stent struts per cross\u2010section score (RUTTS) and neointimal thickness and area were measured at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OCT imaging showed that compared with PR, PE showed a significantly lower prestent thrombus score (34.2\u2009\u00b1\u200919.2 vs. 68.6\u2009\u00b1\u200944.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.009) at baseline and a smaller poststent ISS volume (0.7\u2009\u00b1\u20090.9 mm<jats:sup>3<\/jats:sup> vs. 2.1\u2009\u00b1\u20091.9 mm<jats:sup>3<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.019). At the 6\u2010month follow\u2010up, PE showed a higher incidence of RUTTS &gt;0.3 (12.2\u2009\u00b1\u200914.4 vs. 2.0\u2009\u00b1\u20094.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), thinner neointimal thickness (0.05\u2009\u00b1\u20090.02 mm vs. 0.12\u2009\u00b1\u20090.08 mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), and smaller neointimal area (0.5\u2009\u00b1\u20090.2 vs. 1.2\u2009\u00b1\u20090.9 mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) compared with PR. In a multivariate logistic model, PE was identified as an independent predictor for RUTTS &gt;0.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PE was associated with less favorable healing following DES implantation when compared to PR at 6 months, indicating longer dual\u2010antiplatelet therapy may be necessary for patients with PE. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26943","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T11:10:27Z","timestamp":1490008227000},"page":"592-600","source":"Crossref","is-referenced-by-count":23,"title":["Plaque erosion delays vascular healing after drug eluting stent implantation in patients with acute coronary syndrome"],"prefix":"10.1002","volume":"89","author":[{"given":"Sining","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Zhe","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik\u2010Kyung","family":"Jang","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education Harbin 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