{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:06Z","timestamp":1761823926475},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Essen Technology (Beijing, China)"},{"name":"National Key Technology R&D Program in the 13th Five-Year Plan of China","award":["2016YFC1301300"],"award-info":[{"award-number":["2016YFC1301300"]}]},{"name":"Key Project of National 12th Five-Year Research Program of China","award":["2012ZX093016-002"],"award-info":[{"award-number":["2012ZX093016-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to compare the clinical outcomes of 6\u2010month versus 12\u2010month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer\u2010coated sirolimus\u2010eluting stents (BP\u2010SES) implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical outcomes for patients who undergo multiple BP\u2010SES implantation with different DAPT durations are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the I\u2010LOVE\u2010IT 2 trial, 907 patients treated with multiple BP\u2010SES (total stent number \u22652) were assigned to receive 6\u2010month (<jats:italic>n<\/jats:italic>\u2009=\u2009440) or 12\u2010month (<jats:italic>n<\/jats:italic>\u2009=\u2009467) DAPT. The primary endpoint was 12\u2010month target lesion failure (TLF), which is a composite of cardiac death, target vessel myocardial infarction (MI) or clinically indicated target lesion revascularization. The major secondary endpoints were 12\u2010month net adverse clinical events, a composite of all causes of death, MI, stroke, any revascularization and bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of stents per patient between the 6\u2010month and 12\u2010month DAPT group was similar (2.4\u2009\u00b1\u20090.7 vs. 2.4\u2009\u00b1\u20090.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.47). The incidence of 12\u2010month TLF was comparable in the 6\u2010month and 12\u2010month DAPT groups (9.3% vs.7.5%, Log\u2010rank <jats:italic>P<\/jats:italic>\u2009=\u20090.33). However, landmark analysis showed that 12\u2010month DAPT, compared to 6\u2010month DAPT, was associated with a significantly lower risk of TLF (4.8% vs. 2.4%, Log\u2010rank <jats:italic>P<\/jats:italic>\u2009=\u20090.049) at a cost of a slightly increased risk of all bleeding events (0.5% vs. 1.7%, Log\u2010rank <jats:italic>P<\/jats:italic>\u2009=\u20090.07) between 6 and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients treated with multiple BP\u2010SES, 6\u2010 and 12\u2010month DAPT had similar impacts on 12\u2010month clinical outcomes. Additionally, 12\u2010month DAPT might reduce TLF between 6 and 12 months at the cost of a slightly increased risk of all bleeding events. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26947","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T11:10:27Z","timestamp":1490008227000},"page":"555-564","source":"Crossref","is-referenced-by-count":5,"title":["Safety and efficacy of 6\u2010month versus 12\u2010month dual antiplatelet therapy in patients after implantation of multiple biodegradable polymer\u2010coated sirolimus\u2010eluting coronary stents: Insight from the I\u2010LOVE\u2010IT 2 trial"],"prefix":"10.1002","volume":"89","author":[{"given":"Jing","family":"Qi","sequence":"first","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"},{"name":"The Department of Cardiology, The First Clinical College, Liaoning University of Traditional Chinese Medicine Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanmin","family":"Jing","sequence":"additional","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyu","family":"Gao","sequence":"additional","affiliation":[{"name":"The Department of Cardiology, Henan Provincial People's Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likun","family":"Ma","sequence":"additional","affiliation":[{"name":"The Department of Cardiology, Anhui Provincial Hospital Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Cardiology, Third Affiliated Hospital of Liaoning Medical College Jinzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Catheterization Laboratory, Fuwai Hospital, Chinese Academy of Medical Sciences  Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Han","sequence":"additional","affiliation":[{"name":"The Department of Cardiology General Hospital of Shenyang Military Region Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs086"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.279"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6625"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6530"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I7A124"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.167"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000404"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.09.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm355"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003303"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60612-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.043"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.046"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu523"},{"key":"e_1_2_5_20_1","first-page":"2510","article-title":"Three vs twelve months of dual antiplatelet therapy after zotarolimus\u2010eluting stents: The optimize randomized trial","volume":"310","author":"Feres F","year":"2013","journal-title":"JAMA"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.059022"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.043"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.008"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003145"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3775"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.064"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:09:32Z","timestamp":1694650172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":25,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/ccd.26947"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26947","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}