{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:09:33Z","timestamp":1780960173489,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous paravalvular leak (PVL) closure is an alternative treatment option for severely symptomatic, high\u2010surgical risk patients with PVL. Some patients require multiple percutaneous PVL closure procedures. However, the procedural characteristics and success rate of re\u2010do PVL closure have not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to investigate the indications, procedural characteristics, technical success rate, and 30\u2010day major adverse cardiovascular events (MACE) in patients who underwent re\u2010do PVL closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent percutaneous paramitral or paraaortic leak closure at Mayo Clinic, Rochester, Minnesota from 2004 through 2015 were studied. Clinical and procedural characteristics of patients who underwent re\u2010do PVL closure were compared to age\u2010 and sex\u2010matched patients who underwent their first percutaneous PVL closure. Procedure success and 30\u2010day MACE were compared in both the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 223 identified percutaneous PVL closures, 16 (7%) were re\u2010do procedures. Patients who underwent re\u2010do PVL closure were predominantly men (87.5%) with a mean age of 68\u2009\u00b1\u200915 years and an estimated mean Society of Thoracic Surgery (STS) 30\u2010day mortality of 4.6\u2009\u00b1\u20092.8. Half of the re\u2010do PVL closures were performed on mechanical valves and 62.5% were performed on paramitral defects. Indications for re\u2010do PVL closure were: (1) emergence of new significant paravalvular defects in 50%, (2) incomplete index defect closure in 43.75%, and (3) index procedural complication in 6.25% of the cases. Procedural success was 75% in re\u2010do procedures vs. 85.4% in age\u2010 and sex\u2010matched control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.45). Thirty\u2010day MACE was 12.5% in the re\u2010do group compared to 4.2% in the age\u2010 and\u2010sex matched patients who underwent PVL closure for the first time (<jats:italic>P<\/jats:italic>\u2009=\u20090.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Re\u2010do percutaneous PVL closure is feasible with favorable procedural success rate and low 30\u2010day MACE. Development of new paravalvular defects is the most common indication for re\u2010do PVL closure, highlighting the importance of careful longitudinal monitoring and follow\u2010up. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26961","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T06:12:56Z","timestamp":1486707176000},"page":"680-689","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics and outcomes of re\u2010do percutaneous paravalvular leak closure"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-7688","authenticated-orcid":false,"given":"Mohammed A.","family":"Al\u2010Hijji","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sarraf","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Zack","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Malouf","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuyisile T.","family":"Nkomo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison K.","family":"Cabalka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy S.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation Rochester 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