{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:43:34Z","timestamp":1790016214721,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To define the optimal timing for percutaneous pulmonary valve implantation (PPVI) in patients with severe pulmonary regurgitation (PR) after Fallot's Tetralogy (ToF) correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PPVI among the aforementioned patients is mainly driven by symptoms or by severe right ventricular (RV) dilatation\/dysfunction. The optimal timing for PPVI is still disputed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients [age 13.9\u2009\u00b1\u20099.2 years, (range 4.3\u201344.9), male 70%] with severe PR (\u22653 grade) secondary to previous correction of ToF, underwent Melody valve (Medtronic, Minneapolis, MN) implantation, after a pre\u2010stent placement. Full echocardiographic assessment (traditional and deformation analysis) and cardiovascular magnetic resonance evaluation were performed before and at 3 months after the intervention. \u2018Favorable remodelling\u2019 was considered the upper quartile of RV size decrease (&gt;20% in 3 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After PPVI, indexed RV effective stroke volume increased from 38.4\u2009\u00b1\u20099.5 to 51.4\u2009\u00b1\u200910.7 mL\/m<jats:sup>2<\/jats:sup>, (<jats:italic>P<\/jats:italic>\u2009=\u20090.005), while RV end\u2010diastolic volume and strain indices decreased (123.1\u2009\u00b1\u200924.1\u2013101.5\u2009\u00b1\u200918.3 mL\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.005 and \u221223.5\u2009\u00b1\u20092.5 to \u221221\u2009\u00b1\u20092.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively). After inserting pre\u2010PPVI clinical, RV volumetric and deformation parameters in a multiple regression model, only time after last surgical correction causing PR remained as significant regressor of RV remodelling [<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.60, beta\u2009=\u20090.387, 95%CI(0.07\u20130.7), <jats:italic>P<\/jats:italic>\u2009=\u20090.019]. Volume reduction and functional improvement were more pronounced in patients treated with PPVI earlier than 7 years after last RV outflow tract (RVOT) correction, reaching close\u2010to\u2010normal values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early PPVI (&lt;7 years after last RVOT operation) is associated with a more favorable RV reverse remodelling toward normal range and should be considered, before symptoms or RV damage become apparent. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26966","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T12:43:12Z","timestamp":1489581792000},"page":"407-417","source":"Crossref","is-referenced-by-count":13,"title":["Right ventricular remodelling after transcatheter pulmonary valve implantation"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-8353","authenticated-orcid":false,"given":"Efstathios 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