{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T04:02:50Z","timestamp":1696132970079},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to perform a gender\u2010based meta\u2010analysis of the outcome of bivalirudin versus heparin in patients undergoing percutaneous coronary interventions (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Bivalirudin has been shown to decrease major bleeding when compared to heparin\u2009\u00b1\u2009glycoprotein IIb\/IIIa inhibitors (GPI) in patients undergoing PCI. It is unclear, however, if those differences in outcomes are the same for men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included randomized controlled trials (RCTs) that compared bivalirudin to heparin with or without GPI in patients undergoing PCI and reported outcome data that were stratified by gender. Random effect model was used to pool odds ratio (OR) and 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 9 trials with 33,224 patients. Bivalirudin decreased major bleeding when compared to heparin plus routine GPI in both men (OR: 0.51, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and women (OR: 0.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). However, when GPI were used selectively with heparin, the bleeding lowering effect of bivalirudin was statistically significant in men (OR: 0.69, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) but not in women (OR: 0.71, <jats:italic>P<\/jats:italic>\u2009=\u20090.21). When compared to heparin\u2009\u00b1\u2009GPI, there was a nonstatistically significant trend toward lower all\u2010cause mortality with bivalirudin in both men (OR: 0.76, <jats:italic>P<\/jats:italic>\u2009=\u20090.055) and women (OR: 0.79, <jats:italic>P<\/jats:italic>\u2009=\u20090.21). There were no significant differences in major adverse cardiovascular events between heparin and bivalirudin in both men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bivalirudin decreases major bleeding in both men and women when compared to heparin plus routine GPI. However, when compared to heparin alone, the bleeding lowering benefit of bivalirudin is less evident in women. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26985","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T17:38:52Z","timestamp":1490377132000},"page":"735-742","source":"Crossref","is-referenced-by-count":5,"title":["Gender\u2010based outcomes of bivalirudin versus heparin in patients undergoing percutaneous coronary interventions: Meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"90","author":[{"given":"George S.","family":"Mina","sequence":"first","affiliation":[{"name":"Department of Cardiology LSUHSC\u2010Shreveport Shreveport Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Firouzbakht","sequence":"additional","affiliation":[{"name":"Department of Medicine LSUHSC\u2010Shreveport Shreveport 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