{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:22:35Z","timestamp":1777339355255,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>No previous studies have evaluated the performance of the Synergy stent in a large real\u2010life population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the initial real\u2010life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All implanted Synergy stents were compared with other new generation drug eluting stents (n\u2010DES) with &gt;1,000 implantations in Sweden between March 2013 and October 2015. Restenosis, definite stent thrombosis (ST), myocardial infarction (MI) and death rates were assessed using propensity score and Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7,886 of Synergy stents and 64,429 other n\u2010DES (BioMatrix, <jats:italic>N<\/jats:italic>\u2009=\u20091,953; Orsiro, <jats:italic>N<\/jats:italic>\u2009=\u20094,946; Promus Element Plus, <jats:italic>N<\/jats:italic>= 2,543; Promus Premier, <jats:italic>N<\/jats:italic>= 20,414; Xience Xpedition, <jats:italic>N<\/jats:italic>= 7,971, Resolute\/Resolute Integrity, <jats:italic>N<\/jats:italic>\u2009=\u200919,021; Ultimaster, <jats:italic>N<\/jats:italic>\u2009=\u20091,156; Resolute Onyx, <jats:italic>N<\/jats:italic>\u2009=\u20096,425) were implanted in 42,357 procedures.<\/jats:p><jats:p>Restenosis and stent thrombosis occurred in 642 and 314 cases, respectively, in the overall population at 1 year. The cumulative rate of restenosis (1.1% vs. 1.0%, adjusted HR: 1.24 95% CI: 0.88\u20131.75; <jats:italic>P<\/jats:italic>\u2009=\u20090.21) and ST (0.4% vs. 0.5%, adjusted HR: 0.97; 95% CI: 0.63\u20131.50; <jats:italic>P<\/jats:italic>\u2009=\u20090.17) up to 1 year was low in both the Synergy group and the other n\u2010DES group. Death occurred in 5.2% versus 4.5% (adjusted HR: 1.14; 95% CI: 0.96\u20131.36; <jats:italic>P<\/jats:italic>\u2009=\u20090.11) and MI in 3.2% versus 3.5%, (adjusted HR: 1.11; 95% CI: 0.93\u20131.33; <jats:italic>P<\/jats:italic>\u2009=\u20090.24) up to 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large real\u2010life population the Synergy stent appears to be safe and effective with a low rate of restenosis and ST comparable with other n\u2010DES. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27030","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T23:49:56Z","timestamp":1495583396000},"page":"881-887","source":"Crossref","is-referenced-by-count":27,"title":["Real\u2010life clinical outcomes with everolimus eluting platinum chromium stent with an abluminal biodegradable polymer in patients from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5582-8281","authenticated-orcid":false,"given":"Giovanna","family":"Sarno","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center, Uppsala University Uppsala Sweden"},{"name":"UCR, Uppsala Clinical Research Center Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lagerqvist","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center, Uppsala University Uppsala Sweden"},{"name":"UCR, Uppsala Clinical Research Center Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Olivecrona","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lund University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Varenhorst","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center, Uppsala University Uppsala Sweden"},{"name":"UCR, Uppsala Clinical Research Center Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Danielewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Karlstad Hospital Karlstad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Hambraeus","sequence":"additional","affiliation":[{"name":"Department of Cardiology Falun Lasarett Falun Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center, Uppsala University Uppsala Sweden"},{"name":"UCR, Uppsala Clinical Research Center Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truls","family":"R\u00e5munddal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital G\u00f6teborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Cardiology S\u00f6dersjukhuset University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center, Uppsala University Uppsala Sweden"},{"name":"UCR, Uppsala Clinical Research Center Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200409000-00003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.10065"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61244-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25993"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr479"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.12.057"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002372"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067722"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809902"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.108.844985"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.054"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.067"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61852-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu210"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31920-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61962-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61794-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003610"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01268-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01989-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128850.84227.FD"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002427"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:33:18Z","timestamp":1695731598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,22]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11,15]]}},"alternative-id":["10.1002\/ccd.27030"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27030","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,22]]}}}