{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:11:28Z","timestamp":1740103888052,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,2,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lingering controversy in the current literature about the impact of late incomplete stent apposition (LISA) on clinical outcomes, especially stent thrombosis (ST). Therefore, we aimed to synthesize the available evidence evaluating the association between LISA and adverse clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched electronic databases for studies reporting clinical outcomes in patients with and without LISA. Relevant study characteristics and clinical outcomes were extracted. Incidence rate ratios (IRR) and 95% Confidence Interval (CI) were computed. Sensitivity analyses were done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies with 4,946 patients; 666 patients with 20,035 patient\u2010months follow up with LISA and 4,280 patients with 121,855 patient\u2010months follow up without LISA were included. The estimated prevalence of LISA at follow up was 16% (95% CI 12\u201320%). The incidences of late\/very late ST (IRR\u2009=\u20094.81, 95% CI 2.68\u20138.62) and myocardial infarction (MI) (IRR\u2009=\u20093.09, 95% CI 1.72\u20135.55) were significantly higher in the LISA group compared to patients without LISA. Subset analysis of studies reporting Academic Research Consortium definitive\/probable ST (IRR\u2009=\u20094.98; 95% CI 2.51\u20139.89) and acquired LISA (IRR\u2009=\u20093.67, 95% CI 1.5\u20139.0) similarly showed increased risk of late\/very late ST. The results of sensitivity analyses were consistent. There was no difference in cardiac death and target lesion revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of LISA at a follow up of 6\u201318 months after stent implantation is associated with a higher risk of late\/very late ST and MI. Additional studies are required to establish a cause and effect, and inform the management strategy. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27102","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T11:39:42Z","timestamp":1496144382000},"page":"365-375","source":"Crossref","is-referenced-by-count":11,"title":["Late Incomplete stent apposition is associated with late\/very late stent thrombosis: A meta\u2010analysis"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4757","authenticated-orcid":false,"given":"Ankur","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Icahn School of Medicine at Mount Sinai New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Singbal","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujjwal","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Icahn School of Medicine at Mount Sinai New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoy S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loma Linda University  California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.031"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.11.004"},{"key":"e_1_2_6_4_1","first-page":"169","article-title":"Drug\u2010eluting stents versus bare metal stents in ST elevation myocardial infarction at a follow\u2010up of three years or longer: A meta\u2010analysis of randomized trials","volume":"17","author":"Sethi A","year":"2012","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.03.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20692"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.658237"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.077"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301220"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm114"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr484"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn553"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103666.25660.77"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.068"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_6_18_1","unstructured":"Available at:http:\/\/handbook.cochrane.org\/chapter_16\/16_9_5_validity_of_methods_of_meta_analysis_for_rare_events.htm(Accessed on August 1 2016)"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0031-0"},{"key":"e_1_2_6_20_1","unstructured":"Guido Schwarzer. meta: General Package for Meta\u2010Analysis. 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