{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:23:48Z","timestamp":1774542228742,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe acute and mid\u2010term results of hybrid perventricular device closure of muscular ventricular septal defects (mVSDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Perventricular device closure of mVSDs can mitigate technical limitations of percutaneous closure and need for cardiopulmonary bypass or ventriculotomy with a surgical approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter retrospective cohort study of patients undergoing hybrid perventricular mVSD device closure from 1\/2004 to 1\/2014. Procedural details, adverse events, outcomes, and follow\u2010up data were collected. Patients were divided into two groups: (1) simple (mVSD closure alone) and (2) complex (mVSD closure with concomitant cardiac surgery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients (60% female) underwent perventricular mVSD device closure at a median age of 5.2 months (IQR 1.8\u20138.9) and weight of 5.1 kg (IQR 4.0\u20136.9). Procedural success was 91% [100% (<jats:italic>n<\/jats:italic>\u2009=\u200922) simple and 84% (<jats:italic>n<\/jats:italic>\u2009=\u200921\/25) complex]. Adverse events occurred in 19% (9\/47) [9% (2\/22) simple and 28% (7\/25) complex]. Hospital length of stay (LOS) was shorter in the simple vs. complex group (4 vs. 14 days, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). At mid\u2010term follow\u2010up of 19.2 months (IQR 2.3\u201343) 90% of pts had complete mVSD closure; none developed late heart block, increased atrioventricular (AV) valve insufficiency or ventricular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perventricular device closure of simple mVSD was associated with a high rate of procedural success, few adverse events, and short hospital LOS. Procedural adverse events were associated with the presence of concomitant complex surgery. Residual mVSD, AV valve insufficiency, or ventricular dysfunction were uncommon at mid\u2010term follow\u2010up. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27121","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T12:03:13Z","timestamp":1494244993000},"page":"281-289","source":"Crossref","is-referenced-by-count":21,"title":["Acute and midterm results following perventricular device closure of muscular ventricular septal defects: A multicenter PICES investigation"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-0543","authenticated-orcid":false,"given":"Robert G.","family":"Gray","sequence":"first","affiliation":[{"name":"University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaji C.","family":"Menon","sequence":"additional","affiliation":[{"name":"University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Ann &amp; Robert H. 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Mott Children's Hospital Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Bingler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University of Missouri Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Breinholt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University of Texas Health Science Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Kenny","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lozier","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Mercy Medical Center Des Moines Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua 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