{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:56:14Z","timestamp":1758632174540,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the long term efficacy and safety of long duration DAPT (L\u2010DAPT) compared to short duration DAPT (S\u2010DAPT) after drug\u2010eluting stent (DES) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Medline, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) to identify randomized controlled trials (RCTs) assessing the clinical impact of L\u2010DAPT versus S\u2010DAPT after DES and have mean follow up period of at least 2 years or longer. Primary end point was stent thrombosis (ST). Secondary endpoints were all\u2010cause mortality, cardiac mortality, myocardial infarction (MI), target vessel revascularization (TVR), thrombolysis in myocardial infarction (TIMI) major bleeding and stroke. Event rates were compared using a random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified five RCTs in which 19,760 patients were randomized to S\u2010DAPT (<jats:italic>N<\/jats:italic>\u2009=\u20099,810) and L\u2010DAPT (<jats:italic>n<\/jats:italic>\u2009=\u20099,950), respectively. Compared with L\u2010DAPT, S\u2010DAPT was associated with higher rate of MI (odds ratio [OR] 1.48, 95% confidence interval [CI] [1.04, 2.10]). There were no significant differences between S\u2010DAPT and L\u2010DAPT in terms of all cause mortality, cardiac mortality, ST, TVR or stroke (OR 0.90, 95% CI [0.73, 1.12]; OR 1.02, 95% CI [0.80, 1.30]; OR 1.59, 95% CI [0.77, 3.27]; OR 0.87 95% CI [0.67, 1.14]; and OR 1.08 95% CI [0.81, 1.46], respectively). However, rate of TIMI major bleeding was significantly lower with S\u2010DAPT compared to L\u2010DAPT (OR 0.64, 95% CI [0.41, 0.99]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present analysis of RCTs with longer follow up (2 years or longer), S\u2010DAPT compared with L\u2010DAPT, was associated with higher rate of MI and lower rate of major bleeding without any significant difference in the rates of all cause mortality, cardiac mortality, ST, TVR, and stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27123","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T11:38:43Z","timestamp":1496144323000},"page":"31-37","source":"Crossref","is-referenced-by-count":15,"title":["Duration of dual antiplatelet therapy following drug\u2010eluting stent implantation: A systemic review and meta\u2010analysis of randomized controlled trials with longer follow up"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-5440","authenticated-orcid":false,"given":"Abhishek","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine State University of New York Downstate Medical Center New York New York"},{"name":"Institute of Cardiovascular Science and Technology Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-7807","authenticated-orcid":false,"given":"Sahil","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Luke's University Health Network Bethlehem Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Medicine St. Peter's University Hospital, Rutgers\\Robert Wood Johnson Hospital New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Vallakati","sequence":"additional","affiliation":[{"name":"Division of Cardiology Metrohealth Medical Center, Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"Lavie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases John Ochsner Heart and Vascular Institute, Ochsner Clinical School\u2010the University of Queensland School of Medicine New Orleans Lousiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Helft","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, H\u00f4pital Piti\u00e9\u2010Salp\u00e9tri\u00e8re, Assistance Publique H\u00f4pitaux de Paris, Universit\u00e9 Pierre et Marie Curie, boulevard de l'H\u00f4pital Paris France"},{"name":"Institute of Cardiometabolism and Nutrition, H\u00f4pital Piti\u00e9\u2010Salp\u00e9tri\u00e8re Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001266"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.059022"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.071589"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu523"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_2_7_11_1","first-page":"365","article-title":"Stopping or continuing clopidogrel 12 months after drug\u2010eluting stent placement: The OPTIDUAL randomized trial","volume":"37","author":"Helft G","year":"2016","journal-title":"Eur Heart J"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.513"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116202.41966.D4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu505"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60263-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1618"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.039"},{"key":"e_1_2_7_23_1","first-page":"378","article-title":"Causes of late mortality with dual antiplatelet therapy after coronary stents","volume":"37","author":"Mauri L","year":"2016","journal-title":"Eur Heart J"},{"key":"e_1_2_7_24_1","unstructured":"U.S. Food and Drug Administration. FDA drug safety communication: FDA review finds long\u2010term treatment with blood\u2010thinning medicine Plavix (clopidogrel) does not change risk of death. Available at:http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm471286.htm. Published November 6 2015; updated December 9 2015 accessed October 7 2016."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.047"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3775"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.27123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T16:44:50Z","timestamp":1693241090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ccd.27123"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27123","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}