{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:55:30Z","timestamp":1785610530099,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basel Cardiovascular Research Foundation, Basel, Switzerland"},{"name":"Swiss National Foundation for Research, Berne, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare mid\u2010term outcomes between patients undergoing proximal left anterior descending artery (LAD) percutaneous coronary intervention (PCI) with second generation drug\u2010eluting stent (DES) or bare\u2010metal stent (BMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PCI with BMS and first\u2010generation DES have shown to be safe options for the treatment of proximal LAD stenosis, however associated with considerable reintervention rates. Overall, second\u2010generation DES has proven to be superior to BMS and first\u2010generation DES, nevertheless, its effect for proximal LAD PCI has not previously been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 2\u2010year outcomes of 1,100 patients from the BASKET\u2010PROVE I and II trials, referred for proximal LAD PCI with second generation DES (<jats:italic>n<\/jats:italic>\u2009=\u2009680) or BMS (<jats:italic>n<\/jats:italic>\u2009=\u2009420).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative 2\u2010year incidence of major adverse cardiac events (MACE, composite of cardiac death, myocardial infarction (MI) and target vessel revascularization (TVR)) was lower in second generation DES than in BMS treated patients (7.3% vs. 12.3%; HR 0.57, 95% CI 0.39\/0.85), mainly driven by a reduced rate of TVR (3.7% vs. 10.0%; HR 0.35, CI 0.21\/0.58). No difference was found in cardiac death (1.9% vs. 1.9%; HR 1.01, CI 0.42\/2.44) and MI (4.4% vs. 4.7%; HR 0.93, CI 0.53\/1.64). The benefit of DES use seemed to be more prominent in female patients with a reduction in MACE (<jats:italic>P<\/jats:italic> for interaction\u2009=\u20090.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with proximal LAD stenosis, treatment with second\u2010generation DES was associated with reduced 2\u2010year rates of adverse cardiac events and TVR compared to BMS, with reintervention rates similar to those earlier reported from bypass surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27200","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T11:57:57Z","timestamp":1500465477000},"page":"867-873","source":"Crossref","is-referenced-by-count":5,"title":["Second generation drug\u2010eluting stents <i>versus<\/i> bare\u2010metal stents for percutaneous coronary intervention of the proximal left anterior descending artery: An analysis of the BASKET\u2010PROVE I and II trials"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-1732","authenticated-orcid":false,"given":"Fernanda Marinho","family":"Mangione","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School Boston Massachusetts"},{"name":"Department of Interventional Cardiology Benefic\u00eancia Portuguesa de S\u00e3o Paulo Hospital S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Biering\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nochioka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tohoku University Graduate School of Medicine, Clinical Research, Innovation and Education Center, Tohoku University Hospital Tohoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-2131","authenticated-orcid":false,"given":"Tannas","family":"Jatene","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odilson Marcos","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Wadt","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital, University of Copenhagen Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Skov","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-8944","authenticated-orcid":false,"given":"Peter Godsk","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital, University of Copenhagen Copenhagen 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