{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:04:39Z","timestamp":1761948279915,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed at assessing the performance of a new generation polymer\u2010free biolimus\u2010eluting stent (BES) in real\u2010world patients with ST\u2010segment elevation myocardial infarction (STEMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymers components of early\u2010generation drug\u2010eluting stents have been implicated in the pathogenesis of delayed arterial healing, vessel remodeling, and delayed stent thrombosis. Recently, a novel polymer\u2010free BES has shown excellent clinical performance in clinical trial setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 175 consecutive patients (64\u2009\u00b1\u200914 years, 141 men) treated with the BioFreedom (Biosensors Europe, Morges, Switzerland) polymer\u2010free BES because of STEMI were included in this study. The primary endpoint was the rate of major adverse cardiac events (MACE), a composite of cardiac death, recurrent myocardial infarction, and ischemia\u2010driven target vessel revascularization at 1\u00a0year follow\u2010up. A subgroup of patients underwent 6\u2010month angiographic follow\u2010up. Dual antiplatelet therapy was prescribed for 12 months after STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u00a0year, the cumulative rate of MACE was 4.6%. One patient (0.6%) had an arrhythmic cardiac death and five (2.9%) had ischemia\u2010driven target vessel revascularization, although only three (1.7%) had target lesion revascularization. Two (1.1%) patients had acute stent thrombosis yielding nonfatal myocardial infarction. In 70 patients (63\u2009\u00b1\u200914 years, 61 men), quantitative coronary angiography at 6\u2010month follow\u2010up revealed diameter stenosis of 24.1\u2009\u00b1\u200913.7% and minimal lumen diameter of 2.29\u2009\u00b1\u20090.56 mm, yielding a late lumen loss of 0.13\u2009\u00b1\u20090.14 mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In real\u2010world setting, implantation of a new\u2010generation polymer\u2010free BES during STEMI is associated with favorable clinical and angiographic results, pointing toward the overall efficacy and safety of the device in complex clinical scenarios.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27206","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T09:38:57Z","timestamp":1501666737000},"page":"851-858","source":"Crossref","is-referenced-by-count":9,"title":["Angiographic and clinical performance of polymer\u2010free biolimus\u2010eluting stent in patients with 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