{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:02:29Z","timestamp":1784721749392,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T00:00:00Z","timestamp":1500681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of the study was to investigate the safety and efficacy of the coronary orbital atherectomy system to treat severe coronary artery calcification (CAC) prior to stent placement in diabetic and non\u2010diabetic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The ORBIT II study reported the safety and efficacy of orbital atherectomy treatment in 443 patients with severe CAC. Percutaneous coronary intervention in diabetic patients is associated with an increased risk of major adverse cardiac events (MACE) compared with non\u2010diabetics. The outcomes of diabetic patients who undergo orbital atherectomy are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were sub\u2010grouped as either diabetic (160\/443, 36.1%) or non\u2010diabetic (283\/443, 63.9%). The MACE rate, defined as cardiac death, myocardial infarction (MI; CK\u2010MB\u2009&gt;\u20093X ULN), and target vessel revascularization, was examined at 30 days and 1 year after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Procedural success was similar in the diabetic and non\u2010diabetic groups (89.3 vs. 88.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.88). There was no significant difference in the 30\u2010day and 1\u2010year MACE rates between the diabetic and non\u2010diabetic groups (30 day: 8.8 vs. 11.3%; <jats:italic>P<\/jats:italic>\u2009=\u20090.40; 1 year: 17.1 vs. 16.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.97). The individual components of cardiac death (3.9 vs. 2.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.58), MI (9.4 vs. 11.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.52), and target vessel revascularization (5.9 vs. 5.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.99) were also similar in both groups at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rates of adverse clinical events in diabetic patients who underwent orbital atherectomy were low and similar to non\u2010diabetic patients. This study suggests orbital atherectomy is a reasonable treatment strategy for diabetic patients with severe CAC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27208","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T09:02:46Z","timestamp":1500714166000},"page":"1018-1025","source":"Crossref","is-referenced-by-count":5,"title":["Impact of diabetes mellitus on procedural and one year clinical outcomes following treatment of severely calcified coronary lesions with the orbital atherectomy system: A subanalysis of the ORBIT II study"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-6166","authenticated-orcid":false,"given":"Michael S.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology UCLA Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J.","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Clinical Department Cardiovascular Systems Inc. St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Lee","sequence":"additional","affiliation":[{"name":"The Cardiac and Vascular Institute Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann N.","family":"Behrens","sequence":"additional","affiliation":[{"name":"Clinical Department Cardiovascular Systems Inc. St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Francis Hospital\u2014The Heart Center Roslyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Utah Cardiology Layton Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Metropolitan Heart and Vascular Institute, Mercy Hospital Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00618-8"},{"key":"e_1_2_9_3_1","volume-title":"National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United 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