{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:44:35Z","timestamp":1767109475152,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare follow\u2010up outcomes after percutaneous coronary intervention with drug\u2010eluting stents (DES\u2010PCI) versus coronary artery bypass grafting (CABG) for left\u2010main coronary artery disease (LMCAD), we performed a meta\u2010analysis of randomized controlled trials (RCTs) and observational studies with propensity\u2010score analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched through November 2016. Eligible studies were RCTs or observational studies with propensity\u2010score analysis of DES\u2010PCI versus CABG enrolling patients with LMCAD and reporting\u2009\u2265\u20096\u2010month mortality, myocardial infarction (MI), stroke, or repeat revascularization (RRV). Study\u2010specific estimates were combined using inverse variance\u2010weighted averages of logarithmic hazard ratios (HRs) in the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 5 RCTs and 17 observational studies with propensity\u2010score analysis enrolling a total of 12,387 patients. Pooled analysis demonstrated a significant increase in a composite of death, MI, and RRV (with\/without stroke) after DES\u2010PCI (HR, 1.42; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001); no significant difference in a composite of death and MI (with\/without stroke); no significant differences in mortality and stroke; a strong trend toward an increase in MI after DES\u2010PCI (HR, 1.44; <jats:italic>P<\/jats:italic>\u2009=\u20090.05); and significant increases in any (HR, 1.86; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001), target\u2010vessel (HR, 3.28; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001), and target\u2010lesion RRV (HR, 2.26; <jats:italic>P<\/jats:italic>\u2009=\u20090.003) after DES\u2010PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When compared with CABG, DES\u2010PCI for LMCAD was associated with increases in RRV and the composite of death, MI, and RRV (with\/without stroke), despite no differences in mortality, MI, stroke, and the composite of death and MI (with\/without stroke).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27235","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T11:22:55Z","timestamp":1502450575000},"page":"697-709","source":"Crossref","is-referenced-by-count":4,"title":["Drug\u2010eluting stents versus coronary artery bypass grafting for left\u2010main coronary artery disease"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-8072","authenticated-orcid":false,"given":"Hisato","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8234","authenticated-orcid":false,"given":"Tomo","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology Detroit Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Umemoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ALICE (All\u2010Literature Investigation of Cardiovascular Evidence) Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.03.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32052-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610227"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.178968"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715578066"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.03.057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.02.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs204"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0747"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5935\/1678-9741.20130013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-133"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.07.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004729"},{"volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","year":"2011","author":"Deeks JJ","key":"e_1_2_7_17_1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1303"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.033"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006689"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.038"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300753"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.03.022"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.06.060"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.03.029"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22992"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0262-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.097"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.03.014"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.036"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.353"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2009.00503.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.02.007"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.05.059"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm403"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.9.2335"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-10-200711200-00185"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.090"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2015.01.002"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.135"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T17:09:14Z","timestamp":1695661754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/ccd.27235"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27235","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}