{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:13:35Z","timestamp":1788264815436,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We clarified characteristics and clinical outcomes of critical limb ischemia (CLI) patients who underwent repeat endovascular therapy (EVT) for infrapopliteal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>High restenosis rate after infrapopliteal EVT remains a major concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CLI who underwent EVT between April 2007 and February 2014, were divided into the following three groups according to how often EVT was repeated: Group A, no repeat of EVT; Group B, EVT repeated once\/twice; and Group C, EVT repeated \u22653 times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Wound healing rates at 1 year were 93.9% in Group A, 77.1% in Group B, and 27.3% in Group C (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Limb salvage rates at 3 years were 93.0, 88.5, and 57.1%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Amputation\u2010free survival rates at 3 years were 60.8, 51.2, and 29.2%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.019). Multivariate analysis revealed that hemodialysis (OR 3.413, 95% CI 1.263\u20139.225, <jats:italic>P<\/jats:italic>\u2009=\u20090.016), low ejection fraction (OR 7.758, 1.049\u201357.360, <jats:italic>P<\/jats:italic>\u2009=\u20090.045), and clinical stage assessed by SVS WIfI (OR 2.440, 1.417\u20134.203, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) were independent predictors of repeat EVT. The rate of requirement for repeat EVT significantly increased as clinical stage became more severe (repeat EVT rate: 0% in CS 1, 28.6% in CS 2, 34.0% in CS 3, and 45.7% in CS 4, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical outcomes of CLI patients requiring repeat EVT three or more times were poor. The SVS WIfI clinical stage may be useful to predict the necessity of repeat EVT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27238","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T11:22:46Z","timestamp":1502450566000},"page":"505-514","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics and clinical outcomes of repeat endovascular therapy after infrapopliteal balloon angioplasty in patients with critical limb ischemia"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-0621","authenticated-orcid":false,"given":"Norihiro","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoharu","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-867X","authenticated-orcid":false,"given":"Shinsuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohsuke","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010city Eastern Hospital Yokohama Kanagawa 230\u20108765 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