{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T23:34:02Z","timestamp":1744500842843,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the long\u2010term safety and clinical efficacy of the Genous endothelial progenitor cell capturing stent (ECS) compared with the TAXUS Libert\u00e9 paclitaxel\u2010eluting stent (PES) in lesions with a high risk of restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Instead of the use of cytotoxic or cytostatic drugs in drug\u2010eluting stents, a \u201cpro\u2010healing\u201d approach in ECS may overcome impeded healing response due to delayed functional endothelialization of the stent struts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the prospective, randomized TRIAS pilot study 193 patients with coronary artery lesions carrying a high risk of restenosis were included (ECS: <jats:italic>n<\/jats:italic>\u2009=\u200998, PES: <jats:italic>n<\/jats:italic>\u2009=\u200995). The primary focus of this analysis was target vessel failure (TVF) at 5 years. Dual antiplatelet therapy was prescribed for \u22651 month after ECS and for \u22656 months after PES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 5 years follow\u2010up, no significant differences were found in TVF (ECS 24% vs. PES 29%, risk difference 95% confidence interval (RDCI) \u221217.3% to 7.4%). Between 2 and 5 years after the index procedure, low numbers of TVF were observed in ECS compared with PES (ECS 4% vs. PES 16%, RDCI \u221220.8% to \u22122.3%). There was no definite stent thrombosis in ECS compared with four patients in the PES group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first randomized study providing very long\u2010term clinical efficacy and safety of the ECS in lesions carrying a high risk of restenosis. At 5 years follow\u2010up, TVF rates in ECS group are numerically lower compared with PES due to an increase of events between 2 and 5 years after the index procedure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27249","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T07:22:41Z","timestamp":1504509761000},"page":"1212-1218","source":"Crossref","is-referenced-by-count":6,"title":["Five\u2010year follow\u2010up of the endothelial progenitor cell capturing stent versus the paxlitaxel\u2010eluting stent in de novo coronary lesions with a high risk of coronary restenosis"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-9923","authenticated-orcid":false,"given":"Pier","family":"Woudstra","sequence":"first","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah N.","family":"Kalkman","sequence":"additional","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel A.","family":"Beijk","sequence":"additional","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margo","family":"Klomp","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leids University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Damman","sequence":"additional","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel T.","family":"Koch","sequence":"additional","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose P. 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