{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:47:28Z","timestamp":1762980448508,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the safety, efficacy, and efficiency of the PlasmaWire<jats:sup>TM<\/jats:sup> System to recanalize coronary chronic total occlusions (CTO) using controlled ablation inside the CTO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The PlasmaWire<jats:sup>TM<\/jats:sup> System is a new bipolar radiofrequency (RF) wire system utilizing plasma\u2010mediated ablation to facilitate wire crossing in CTOs. Two independent PlasmaWire<jats:sup>TM<\/jats:sup> wires are used in tandem for channel creation by applying RF energy between the tips so as to localize the ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, nonrandomized, single\u2010arm, multicenter study in seven patients with CTOs indicated for percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, both wires were antegradely delivered to the distal end of CTO for antegrade re\u2010entry in two cases and bidirectionally (antegrade and retrograde) delivered to the CTO for retrograde re\u2010entry in five cases. In all cases, channel creation was achieved within a few seconds and was confirmed on angiogram or intravascular ultrasound (IVUS) and CTO recanalization was successfully achieved without any major adverse cardiac and cerebrovascular events (MACCE) or other minor complications. The clinical follow\u2010up showed no clinical event at 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PlasmaWire<jats:sup>TM<\/jats:sup> System was shown to be safe and effective in obtaining CTO recanalization through a re\u2010entry channel utilizing plasma\u2010mediated ablation while reducing procedure time. The PlasmaWire\u2122 System is a new bi\u2010polar RF wire system utilizing plasma\u2010mediated ablation for channel creation to facilitate CTO recanalization. This first\u2010in\u2010human study in which seven patients were enrolled was conducted to demonstrate the safety, efficacy, and efficiency of this system for CTO recanalization. Channels through the CTOs were successfully created within a few seconds by applying RF energy between the tips of two independent PlasmaWire<jats:sup>TM<\/jats:sup> wires and recanalization was achieved in all cases without any complication. The PlasmaWire<jats:sup>TM<\/jats:sup> System may safely facilitate CTO recanalization with less vessel injury and improve initial results of CTO PCI while reducing procedure time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27333","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T05:18:39Z","timestamp":1507180719000},"page":"1045-1051","source":"Crossref","is-referenced-by-count":11,"title":["<scp>I<\/scp>nitial results of a first\u2010in\u2010human study on the PlasmaWire\u2122 System, a new radiofrequency wire for recanalization of chronic total occlusions"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-3608","authenticated-orcid":false,"given":"Daitaro","family":"Kanno","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo Cardio Vascular Clinic Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuo","family":"Tsuchikane","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Toyohashi Heart Center Toyohashi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Nasu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Toyohashi Heart Center Toyohashi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Katoh","sequence":"additional","affiliation":[{"name":"RetroVascular Inc Pleasanton California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo Cardio Vascular Clinic Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umihiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo Cardio Vascular Clinic Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Sapporo Cardio Vascular Clinic Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriyasu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nagoya Heart Center Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Toyohashi Heart Center Toyohashi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01349-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.583716"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10505"},{"key":"e_1_2_7_5_1","first-page":"334","article-title":"New concept for CTO recanalization using controlled antegrade and retrograde subintimal tracking: The CART technique","volume":"18","author":"Surmely JF","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.09.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80352-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2001.tb00379.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000243637.23923.A7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I2A33"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00400.x"},{"key":"e_1_2_7_14_1","first-page":"575","article-title":"Radio frequency perforation of cardiac tissue: Modelling and experimental results. 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