{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:47:38Z","timestamp":1789642058891,"version":"4.0.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T00:00:00Z","timestamp":1506729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the impact of post transcatheter aortic valve implantation (TAVI) mild paravalvular regurgitation (PVR) on mortality. More than moderate PVR after TAVI has decreased with the advent of new\u2010generation prosthetic valves. However, mild PVR remains common and its clinical impact has been inconsistent. We aimed to assess the impact of mild PVR through meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A systematic literature search was conducted through PUBMED and EMBSE. Manuscripts that reported hazard ratio (HR) with 95% confidence interval (CI) for clinical outcome of interest (all\u2010cause and cardiac mortality) has been included. Random\u2010effects model was used for calculation of HR. A total of 25 articles including total of 21,018 patients were finally included for quantitative synthesis (meta\u2010analysis). Our pooled analysis demonstrated higher all\u2010cause mortality in patients with mild PVR compared to none\/trivial PVR (HR 1.26, 95%CI 1.11\u20131.43, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=45%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) (follow up duration range 6 months to 5 years). Significant heterogeneity among studies was observed (<jats:italic>p<\/jats:italic> for heterogeneity\u2009=\u20090.005). Egger's test showed no evidence of publication bias. Cardiovascular mortality was increased in patients with mild PVR compared with none\/trivial PVR (HR 1.28, 95%CI 1.05\u20131.57, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>=8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) (follow up duration range 1\u20133 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mild PVR was associated with increased all\u2010cause and cardiovascular mortality after TAVI. Whether further interventions in mild PVR is of benefit, has yet to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27336","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T06:32:48Z","timestamp":1506753168000},"page":"135-147","source":"Crossref","is-referenced-by-count":36,"title":["Does mild paravalvular regurgitation post transcatheter aortic valve implantation affect survival? A meta\u2010analysis"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8234","authenticated-orcid":false,"given":"Tomo","family":"Ando","sequence":"first","affiliation":[{"name":"Division of Cardiology Wayne State University, Harper Hospital Detroit Michigan"},{"name":"ALICE (All\u2010Literature Investigation Cardiovascular Evidence) group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"Division of Heart Failure Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7120-0577","authenticated-orcid":false,"given":"Tesfaye","family":"Telila","sequence":"additional","affiliation":[{"name":"Division of Cardiology Wayne State University, Harper Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Afonso","sequence":"additional","affiliation":[{"name":"Division of Cardiology Wayne State University, Harper Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Grines","sequence":"additional","affiliation":[{"name":"Division of Cardiology Detroit Medical Center Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-8072","authenticated-orcid":false,"given":"Hisato","family":"Takagi","sequence":"additional","affiliation":[{"name":"ALICE (All\u2010Literature Investigation Cardiovascular Evidence) group"},{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.159"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30073-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12356"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60308-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu384"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.050"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022797"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002677"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.047"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.09.016"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.08.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.08.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305390"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.04.016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.964213"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000249"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.04.012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M12_08"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.05.023"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.03.099"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu290"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.07.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I12A213"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.059"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.12.271"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.115.003665","article-title":"Two\u2010year outcomes in patients with severe aortic valve stenosis randomized to transcatheter versus surgical aortic valve replacement: The all\u2010comers nordic aortic valve intervention randomized clinical trial","volume":"9","author":"S\u00f8ndergaard L","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.athoracsur.2014.05.084","article-title":"Transapical aortic valve implantation: predictors of leakage and impact on survival: An update","volume":"98","author":"Unbehaun A","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.02.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.005"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr259"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.07.013"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.01.008"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114705"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.03.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu413"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2013.12.013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22212"},{"key":"e_1_2_7_47_1","first-page":"494","article-title":"Aortic valve calcification as quantified with multislice computed tomography predicts short\u2010term clinical outcome in patients with asymptomatic aortic stenosis","volume":"15","author":"Feuchtner GM","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.08.070"},{"key":"e_1_2_7_49_1","first-page":"41","article-title":"Value of CMR in quantification of paravalvular aortic regurgitation after TAVI","volume":"17","author":"Salaun E","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.07.013"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.01.007"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.000115"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202277"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.960"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.026"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.556"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.145"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.190"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:17:47Z","timestamp":1695910667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,30]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/ccd.27336"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27336","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,30]]}}}