{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:16:55Z","timestamp":1780705015115,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the recently concluded PARTNER 2 trial, TF\u2010TAVR cohort was shown to have lower risks of death or disabling strokes as compared to SAVR, whereas the outcomes with transthoracic TAVR were comparable with SAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, EMBASE, Web of Science, and Google Scholar for all comparison studies between TAVR and SAVR and mortality as an outcome, irrespective of surgical risk. Randomized controlled trials and propensity\u2010score\u2010matched cohort studies that used a transfemoral approach exclusively or stratified results by route of access and reported data for TF\u2010TAVR patients were eligible for inclusion. Outcomes of interest included 30\u2010day and 1\u2010year mortality, and 30\u2010day complications. If significant heterogeneity was found in the random effects meta\u2010analyses, a sensitivity analysis which individually removed each study was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies reported results on TF\u2010TAVR. Compared with SAVR, TF\u2010TAVR had comparable 30\u2010day mortality (RR 0.79, 95% CI 0.58, 1.06), 1\u2010year mortality (RR 0.91, 95% CI 0.78, 1.08) and 30\u2010day risk of bleeding (RR 0.70, 95% CI 0.31, 1.57). However, TF\u2010TAVR was associated with lower 30\u2010day risks of atrial fibrillation (RR 0.28, 95% CI 0.17, 0.45), acute kidney injury (RR 0.38, 95% CI 0.20, 0.71), and myocardial infarction (RR 0.41, 95% CI 0.23, 0.75) at a cost of higher incidences of vascular complications (RR 6.10, 95% CI 2.92, 12.73) and pacemaker implantations (RR 3.29, 95% CI 1.41, 7.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TF\u2010TAVR is associated with lower 30\u2010day risks of myocardial infarction compared to SAVR. Further studies are required to investigate the role of myocardial injury on overall TF\u2010TAVR outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27357","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T11:44:37Z","timestamp":1508931877000},"page":"806-812","source":"Crossref","is-referenced-by-count":15,"title":["Meta\u2010analysis of transfemoral <scp>TAVR<\/scp> versus surgical aortic valve replacement"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-3015","authenticated-orcid":false,"given":"Sameer","family":"Arora","sequence":"first","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina 27599\u20107075"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayana R.","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Cape Fear Valley Medical Center Fayetteville North Carolina 28304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula D.","family":"Strassle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina Chapel Hill North Carolina 27599\u20107400"},{"name":"Department of Surgery UNC School of Medicine Chapel Hill North Carolina 27599\u20107050"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Misenheimer","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina 27599\u20107075"},{"name":"Division of Cardiology The Medical College of Georgia at Augusta University Augusta Georgia 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Campbell University School of Osteopathic Medicine Lillington North Carolina 27546"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra J.","family":"Ramm","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina 27599\u20107075"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan N.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Campbell University School of Osteopathic Medicine Lillington North Carolina 27546"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Caranasos","sequence":"additional","affiliation":[{"name":"Department of Surgery UNC School of Medicine Chapel Hill North Carolina 27599\u20107050"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Cavender","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina 27599\u20107075"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Vavalle","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina 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