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Our aim was to synthesize the available evidence from randomized clinical trials (RCTs) and observational studies that directly compare second\u2010generation drug\u2010eluting stents (SG\u2010DES) and DCB for the treatment of coronary ISR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline, Embase, and Cochrane Central were searched for RCTs or observational studies, published up to March 15, 2017. A random effects model meta\u2010analysis investigating clinical and angiographic outcomes was conducted for RCTs and observational studies that compared SG\u2010DES versus DCB for the treatment of ISR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies and 2,173 patients were included in this meta\u2010analysis. The two treatment strategies were proven equal with regards to TLR, myocardial infarction, stent thrombosis, and cardiac mortality in both randomized and observational studies. No difference was found among RCTs for all\u2010cause mortality, while in observational studies, patients who were treated with SG\u2010DES had a lower mortality compared to DCB (OR: 0.47; 95% CI: 0.27\u20130.83). In the pooled analysis also (RCTs and observational studies), SG\u2010DES were associated with lower all\u2010cause mortality compared to DCB. Patients treated with SG\u2010DES were also superior in terms of minimal lumen diameter (standardized mean difference: 0.39; 95% CI: 0.12\u20130.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The two treatment strategies are equal for the treatment of ISR, while the difference in all\u2010cause mortality might be potentially explained by baseline differences in the two groups among real\u2010world studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27359","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T12:10:10Z","timestamp":1507637410000},"page":"285-299","source":"Crossref","is-referenced-by-count":9,"title":["Second\u2010generation drug\u2010eluting stents versus drug\u2010coated balloons for the treatment of coronary in\u2010stent restenosis: A systematic review and 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