{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:28Z","timestamp":1740103828588,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to examine predictors and clinical outcomes of periprocedural myocardial infarction (PMI) after chronic total occlusion (CTO) intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data on the clinical implications of PMI after CTO intervention in the new\u2010generation drug\u2010eluting stent (DES) era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 337 patients who underwent CTO intervention and met the study criteria. We evaluated the incidence and predictors of PMI, defined as an increase in creatine kinase\u2010MB \u22653\u00d7 the upper limit of normal (ULN) after intervention and compared the occurrence rates of major adverse cardiac and cerebrovascular events (MACCE, defined as the composite of cardiac death, myocardial infarction, stent thrombosis, target\u2010vessel revascularization, or cerebrovascular accidents) between the PMI and non\u2010PMI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PMI occurred in 23 (6.8%) patients after CTO intervention. Significant independent predictors were previous bypass surgery [odds ratio (OR)\u2009=\u20095.52, 95% confidence interval (CI)\u2009=\u20091.17\u201325.92; <jats:italic>P<\/jats:italic>\u2009=\u20090.03], Japan\u2010CTO score \u22653 (OR\u2009=\u20097.06, 95%CI\u2009=\u20092.57\u201319.39; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), side branch occlusion (OR\u2009=\u20094.21, 95%CI\u2009=\u20091.13\u201315.66; <jats:italic>P<\/jats:italic>\u2009=\u20090.03), and longer procedure time (OR\u2009=\u20094.18, 95%CI\u2009=\u20091.35\u201312.99; <jats:italic>P<\/jats:italic>\u2009=\u20090.01). During a median follow\u2010up of 29.6 months, the PMI group had a significantly higher MACCE rate than the non\u2010PMI group (23.7 vs. 5.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.008 by log\u2010rank test). PMI was an independent predictor of MACCE (HR\u2009=\u20094.26, 95%CI\u2009=\u20091.35\u201313.43; <jats:italic>P<\/jats:italic>\u2009=\u20090.01). The MACCE rate gradually increased in a CK\u2010MB\u2010dependent fashion and was highest in patients with \u226510\u00d7 ULN (<jats:italic>P<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous bypass surgery, high Japan\u2010CTO score, side branch occlusion, and longer procedure time were strongly related to PMI occurrence after CTO intervention. PMI was significantly associated with worse clinical outcomes in the new\u2010generation DES era.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27420","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T12:17:47Z","timestamp":1513772267000},"page":"477-485","source":"Crossref","is-referenced-by-count":3,"title":["Incidence, predicting factors, and clinical outcomes of periprocedural myocardial infarction after percutaneous coronary intervention for chronic total occlusion in the era of new\u2010generation drug\u2010eluting stents"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-7859","authenticated-orcid":false,"given":"Jin\u2010Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology Yonsei Cardiovascular Center, Yonsei University College of Medicine Seoul 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