{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:36:11Z","timestamp":1785879371211,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Demonstrate proof\u2010of\u2010concept validation of a computed tomography (CT) computer\u2010aided design prediction modeling tool to identify patients at risk for left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve replacement (TMVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>LVOT obstruction is a significant and even fatal consequence of TMVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From August 2013 to August 2017, 38 patients in 5 centers underwent TMVR with compassionate use of balloon\u2010expandable valves for severe mitral valve dysfunction because of degenerative surgical mitral ring, bioprosthesis, or severe native mitral stenosis from to severe mitral annular calcification. All patients had preprocedural CT scans performed for anatomic screening, intraprocedural TEE and invasive hemodynamics performed. Preprocedural prediction modeling was performed utilizing computer\u2010aided design (CAD) of the neo\u2010LVOT post\u2010TMVR. Post\u2010TMVR CT scans were obtained and compared to pre\u2010TMVR LVOT modeling datasets for validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients underwent successful TMVR without device embolization. Seven of the 38 patients experienced LVOT obstruction, defined as an increase of \u226510 mmHg LVOT peak gradient post\u2010TMVR. Anatomic screening using CT was validated in 20\/38 patients as preprocedural predicted neo\u2010LVOT surface area correlated well with post\u2010TMVR measurements (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.8169, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). A receiver operating curve curve found a predicted neo\u2010LVOT surface area of\u2009\u2264\u2009189.4 mm<jats:sup>2<\/jats:sup> to have 100% sensitivity and 96.8% specificity for predicting TMVR\u2010induced LVOT obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CAD design and CT postprocessing are indispensable tools in predicting LVOT obstruction and necessary for anatomic screening in percutaneous TMVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27447","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T06:42:47Z","timestamp":1512974567000},"page":"379-387","source":"Crossref","is-referenced-by-count":108,"title":["Validating a prediction modeling tool for left ventricular outflow tract (<scp>LVOT<\/scp>) obstruction after transcatheter mitral valve replacement (<scp>TMVR<\/scp>)"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-9924","authenticated-orcid":false,"given":"Dee Dee","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-6504","authenticated-orcid":false,"given":"Marvin H.","family":"Eng","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Myers","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forbes","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Karabon","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Pantelic","sequence":"additional","affiliation":[{"name":"Department of Radiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Nadig","sequence":"additional","affiliation":[{"name":"Department of Radiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":false,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Division of Cardiology Evanston Hospital, North Shore University Health System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IMI.0000000000000139"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.057"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3164"},{"key":"e_1_2_9_5_1","first-page":"1343","article-title":"Seminar on in vitro studies of cardiac flow and their applications for clinical Doppler echocardiography\u2013I","volume":"12","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)91005-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.08.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1208"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26649"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw153"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.036"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.01.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0886-0440.2004.200306.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2014.09.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.41.3.263"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.07.015"},{"key":"e_1_2_9_21_1","first-page":"1131","article-title":"Prediction of postoperative left ventricular systolic function in patients with chronic mitral regurgitation undergoing valve surgery\u2014The role of deformation imaging","volume":"40","author":"Marciniak A","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00464-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-011-0833-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01722-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt234"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.076"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.10.064"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90286-Q"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.01.084"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26649"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26975"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.06.020"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:46:18Z","timestamp":1694954778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/ccd.27447"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27447","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}