{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:49:06Z","timestamp":1762004946230,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfemoral transcatheter aortic valve replacement (TAVR) was superior to surgical aortic valve replacement (SAVR) in the placement of aortic transcatheter valves (PARTNER) 2A trial (P2). The generalizability of the trial results to the broader population of patients with intermediate surgical risk remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the outcomes of SAVR and TAVR among patients with intermediate surgical risk treated in the VA Healthcare System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical characteristics and outcomes on all SAVR (1987\u20132014) and TAVR procedures (2015\u20132017) performed at the Minneapolis VA Healthcare System. Patients were divided into three groups based on their estimated 30\u2010day mortality risk. The primary outcome was a composite of death or stroke at 30\u2010days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,049 patients underwent SAVR with (<jats:italic>n<\/jats:italic>\u2009=\u2009468, 45%) or without CABG (<jats:italic>n<\/jats:italic>\u2009=\u2009581, 55%) and 110 underwent TAVR during the study period. Intermediate\u2010risk patients represented 29.4% and 40% of patients undergoing SAVR and TAVR, respectively. The predicted 30\u2010day mortality risk of intermediate\u2010risk patients was 5.5% for the SAVR group and 5.2% for the TAVR group (<jats:italic>P<\/jats:italic>\u2009=\u20090.54). The observed combined rate of stroke or death at 30\u2010days for intermediate\u2010risk patients treated with SAVR and TAVR was 11% and 2.2%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). The results for SAVR and TAVR at the VA were comparable to the P2 trial and STS database (all <jats:italic>P<\/jats:italic>\u2009=\u2009NS). The results did not change when the analysis was restricted to a more contemporary (2005\u20132014) surgical cohort or isolated SAVR. The number needed to treat to prevent one death\/stroke with TAVR was 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adoption of TAVR as the preferred treatment modality in intermediate\u2010risk patients may result in significant improvements in morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27478","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T13:01:17Z","timestamp":1515589277000},"page":"390-398","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of intermediate\u2010risk patients treated with transcatheter and surgical aortic valve replacement in the Veterans Affairs Healthcare System: A single center 20\u2010year experience"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-8082","authenticated-orcid":false,"given":"Santiago","family":"Garcia","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Minneapolis VA Healthcare System Minneapolis Minnesota"},{"name":"Division of Cardiology, Department of Medicine University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Mbai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Minneapolis VA Healthcare System Minneapolis Minnesota"},{"name":"Division of Cardiology, Department of Medicine University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-915X","authenticated-orcid":false,"given":"Sergey","family":"Gurevich","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Minneapolis VA Healthcare System Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-0054","authenticated-orcid":false,"given":"Brett","family":"Oestreich","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Minneapolis VA Healthcare System Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetris","family":"Yannopoulos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Adabag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Minneapolis VA Healthcare System Minneapolis Minnesota"},{"name":"Division of Cardiology, Department of Medicine University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30073-3"},{"key":"e_1_2_8_6_1","unstructured":"OrtmanJMO GuarneriCE.United States Population Projections: 2000 to 2050. 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