{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:05:01Z","timestamp":1773061501851,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assess the mid\u2010term outcomes of ultrathin biodegradable polymer double stenting using a very minimal crushing (Nano\u2010Crush) technique in large complex coronary bifurcation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Complex bifurcations have been suggested to be better approached by a planned double stent technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and five consecutive patients (107 males and 98 females) referred for large complex coronary bifurcation percutaneous coronary interventions were enrolled. The technique was also evaluated by both a bench test with a silicon tubes phantom resembling a coronary bifurcation and a computed fluid dynamic (CFD) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left main bifurcation accounted for 40.9% of cases (84 patients). Mean angles between main branch (MB) and side branch (SB) were 63.6\u2009\u00b1\u200921.3\u00b0. SB intravascular ultrasound\u2010calculated MSA was 5.6\u2009\u00b1\u20091.5 mm<jats:sup>2<\/jats:sup>. Clinical follow\u2010up was available for 100% of patients and at a mean follow\u2010up of 16.2\u2009\u00b1\u20096.7 months 8 deaths, all due to cardiovascular reason, (3.9%, 4 patients for stroke, two for heart failure, one after surgical aortic valve substitution, and one after acute massive pulmonary embolism) and no presumptive stent thrombosis or target vessel induced ischemia were observed. Angiographic follow\u2010up was available in 108 patients (52.7%) and showed a very low significant restenosis (5 patients, 4.6%). Bench study and CFD evaluation suggested a complete coverage of the SB ostium with a very high strut\u2010free area at the SB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The revascularization of complex large coronary bifurcation disease using the Nano\u2010crush technique appeared promising thanks to the favorable fluid dynamic profile, complete coverage of the SD ostium, and very small metal amount at the carina.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27494","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T06:32:49Z","timestamp":1516861969000},"page":"907-914","source":"Crossref","is-referenced-by-count":11,"title":["Complex coronary bifurcation treatment by a novel stenting technique: Bench test, fluid dynamic study and clinical outcomes"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-3640","authenticated-orcid":false,"given":"Gianluca","family":"Rigatelli","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Diagnosis and Endoluminal Interventions Rovigo General Hospital Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zuin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rovigo General Hospital, Rovigo, Italy and Section of Internal and Cardiopulmonary Medicine, Department of Medical Science University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Dell'Avvocata","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Diagnosis and Endoluminal Interventions Rovigo General Hospital Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobrin","family":"Vassilev","sequence":"additional","affiliation":[{"name":"Head, Department of Cardiology; 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