{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:09:12Z","timestamp":1759183752804,"version":"3.37.3"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Key Points<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Pre\u2010treatment with intact oral clopidogrel and prasugrel tablets in a representative observational study is not associated with altered ischemic or bleeding outcomes in acute coronary syndrome (ACS) patients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Limited by cost, cangrelor, a rapidly acting intravenous P2Y<jats:sub>12<\/jats:sub> platelet receptor inhibitor, achieved meaningful reductions in major adverse cardiovascular events (MACE) and stent thrombosis (ST) compared to oral clopidogrel pretreatment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Crushed prasugrel and ticagrelor (CP&amp;T) administered orally achieve accepted thresholds of therapeutic platelet inhibition in one hour in approximately 2\/3rds of patients compared to 1\/3rd with intact oral tablets. A large, simple randomized trial should test whether CP&amp;T pre\u2010treatment could capture some of the potential outcome benefit of rapid P2Y<jats:sub>12<\/jats:sub> inhibition at no incremental risk and cost.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/ccd.27512","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T12:32:58Z","timestamp":1517920378000},"page":"251-252","source":"Crossref","is-referenced-by-count":1,"title":["The promise of effective P2Y<sub>12<\/sub> platelet receptor pretreatment: Not crushed yet"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-308X","authenticated-orcid":false,"given":"Arka","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Cardiovascular Division, University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-0564","authenticated-orcid":false,"given":"William B.","family":"Hillegass","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Alabama at Birmingham Birmingham Alabama"},{"name":"Department of Biostatistics University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300815"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407024"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308075"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27145"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.024"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:38:57Z","timestamp":1695713937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/ccd.27512"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27512","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}