{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:15:48Z","timestamp":1769382948359,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To synthesize evidence regarding long\u2010term survival after transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) for severe aortic stenosis (AS) from real\u2010world clinical practice, we performed a meta\u2010analysis of observational studies with a propensity\u2010score analysis and \u22653\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases including MEDLINE and EMBASE were searched through April 2017 using PubMed and OVID. Eligible studies were observational comparative studies with a propensity\u2010score analysis of TAVI versus SAVR enrolling patients with severe AS and reporting \u22653\u2010year all\u2010cause mortality as an outcome. A hazard ratio (HR) with its 95% confidence interval (CI) of follow\u2010up (including early) mortality for TAVI versus SAVR was extracted from each individual study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search identified 14 eligible studies enrolling a total of 4,197 patients. A pooled analysis of all the 14 studies demonstrated a statistically significant 54% increase in mortality with TAVI relative to SAVR (HR, 1.54; 95% CI, 1.31\u20131.81;<jats:italic>P<\/jats:italic>for effect\u2009&lt;\u20090.00001;<jats:italic>P<\/jats:italic>for heterogeneity\u2009=\u20090.14;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200930%). Several sensitivity analyses did not substantially change the statistically significant benefit for SAVR. There was no evidence of significant publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On the basis of a meta\u2010analysis of 14 observational comparative studies with a propensity\u2010score analysis including a total of \u22654,000 patients, TAVI is associated with worse \u22653\u2010year overall survival than SAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27521","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T09:14:37Z","timestamp":1517476477000},"page":"419-430","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term survival after transcatheter versus surgical aortic valve replacement for aortic stenosis: A meta\u2010analysis of observational comparative studies with a propensity\u2010score 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