{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:48:11Z","timestamp":1763329691672,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine if fractional flow reserve guided percutaneous coronary intervention (FFR\u2010guided PCI) is associated with reduced ischemic myocardium compared with angiography\u2010guided PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although FFR\u2010guided PCI has been shown to improve outcomes, it remains unclear if it reduces the extent of ischemic myocardium at risk compared with angiography\u2010guided PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 380 patients (190 FFR\u2010guided PCI cases and 190 propensity\u2010matched controls) who underwent PCI from 2009 to 2014. Clinical, laboratory, angiographic, stress testing, and major adverse cardiac events [MACE] (all\u2010cause mortality, recurrence of MI requiring PCI, stroke) data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 63\u2009\u00b1\u200911 years; the majority of patients were males (76%) and Caucasian (77%). Median duration of follow up was 3.4 [Range: 1.9, 5.0] years. Procedural complications including coronary dissection (2% vs. 0%, <jats:italic>P<\/jats:italic>\u2009=\u2009.12) and perforation (0% vs. 0%, <jats:italic>P<\/jats:italic>\u2009=\u20091.00) were similar between FFR\u2010guided and angiography\u2010guided PCI patients. FFR\u2010guided PCI patients had lower unadjusted (14.7% vs. 23.2%, <jats:italic>P<\/jats:italic>\u2009=\u2009.04) and adjusted [OR\u2009=\u20090.58 (95% CI: 0.34\u20130.98)] risk of repeat revascularization at one year. FFR\u2010guided PCI patients were less likely (23% vs. 32%, <jats:italic>P<\/jats:italic>\u2009=\u2009.02) to have ischemia and had lower (5.9% vs. 21.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) ischemic burden (moderate\u2010severe ischemia) on post\u2010PCI stress testing. Presence of ischemia post\u2010PCI remained a strong predictor of MACE [OR\u2009=\u20092.14 (95%CI: 1.28\u20133.60)] with worse survival compared to those without ischemia (HR\u2009=\u20091.63 (95% CI: 1.06\u20132.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with angiography\u2010guided PCI, FFR\u2010guided PCI results in less repeat revascularization and a lower incidence of post PCI ischemia translating into improved survival, without an increase in complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27525","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T09:13:30Z","timestamp":1517908410000},"page":"692-700","source":"Crossref","is-referenced-by-count":2,"title":["Fractional flow reserve guided percutaneous coronary intervention results in reduced ischemic myocardium and improved outcomes"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4443","authenticated-orcid":false,"given":"Abhishek C.","family":"Sawant","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology State University of New York at Buffalo, and Buffalo VA Healthcare System Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology State University of New York at Buffalo, and Buffalo VA Healthcare System Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinjal","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Jobanputra","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parth","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna C.","family":"Kandregula","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanhaiya","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Corbelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology State University of New York at Buffalo, and Buffalo VA Healthcare System Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.4.1354"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.087"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.042"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.990"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.970111"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743963"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01372-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.067736"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2004.03.033"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.10.021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht404"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1595"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408758"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu338"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.12.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002207"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072790.23090.41"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.056"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701067"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.07.007"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:48:48Z","timestamp":1694782128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/ccd.27525"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27525","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2018,2,6]]}}}