{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:27:07Z","timestamp":1780464427684,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic value of physiological indices in non\u2010ST\u2010segment elevation acute coronary syndrome (NSTE\u2010ACS) patients undergoing percutaneous coronary intervention (PCI) is unknown. We investigated the prognostic efficacy of physiological indices obtained after PCI in patients with NSTE\u2010ACS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010three patients (men: <jats:italic>n<\/jats:italic>\u2009=\u200970, age: 63.7\u2009\u00b1\u20099.7 years) undergoing PCI for NSTE\u2010ACS within 48 hr postadmission were investigated. Fractional flow reserve (FFR), coronary flow reserve (CFR), and the index of microcirculatory resistance (IMR) of the culprit vessels were measured after the completion of PCI. The patients were clinically followed up to determine major cardiac adverse events (MACE), including death, congestive heart failure requiring hospitalization, and remote coronary revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median FFR, CFR, and IMR values were 0.90 (interquartile range [IQR] 0.86\u20130.95), 2.38 (IQR 1.75\u20134.17), and 22.9 (IQR 11.2\u201331.5), respectively. During a median follow\u2010up of 20.7 months, 19 MACEs (22.9%) were documented. No significant difference in baseline patient characteristics, except for age, was detected between patients with and without MACE. Patients with MACE showed higher IMR and lower CFR than those without (IMR: 27.2 vs. 16.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.001, CFR: 1.82 vs. 2.55; <jats:italic>P<\/jats:italic>\u2009=\u20090.04), whereas FFR was not significantly different (0.92 vs. 0.89; <jats:italic>P<\/jats:italic>\u2009=\u20090.72), irrespective of the MACE occurrence. Post\u2010PCI IMR was the only independent predictor of MACE (hazard ratio 1.033, 95% confidence interval 1.013\u20131.052, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). The MACE\u2010free survival was significantly worse in patients with high post\u2010PCI IMR (\u03c7<jats:sup>2<\/jats:sup> 7.12; <jats:italic>P<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Post\u2010PCI IMR may help identify patients at high risk for subsequent adverse coronary events who require adjunctive therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27529","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T11:08:41Z","timestamp":1518692921000},"page":"1063-1074","source":"Crossref","is-referenced-by-count":38,"title":["Prognostic value of the index of microcirculatory resistance after percutaneous coronary intervention in patients with non\u2010ST\u2010segment elevation acute coronary syndrome"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-4296","authenticated-orcid":false,"given":"Tadashi","family":"Murai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5008","authenticated-orcid":false,"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-4377","authenticated-orcid":false,"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki 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