{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:36Z","timestamp":1786977216190,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To date, experience with bioresorbable scaffolds (BRS) that elute agents other than everolimus is limited. Thus, a post\u2010marketing clinical follow\u2010up study was conducted to evaluate the continued safety and effectiveness of the DESolve\u00ae NOVOLIMUS\u2122 Eluting BRS as treatment for patients with stable coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The DESolve BRS combines a poly\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010lactide\u2010based backbone with a biodegradable polylactide\u2010based polymer and Novolimus, a macrocyclic lactone mTOR inhibitor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and two patients (mean age 62 years, 77.5% male) were enrolled at 10 European sites. Comparison of baseline and post\u2010procedural angiographic assessment was performed, and a device\u2010oriented composite endpoint (comprising cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and rate of scaffold thrombosis at 12 months were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The device was successfully delivered and deployed in 98.2% (107\/109) of the lesions, with two failures to cross the lesion. A total of 100 patients (109 lesions) were treated with a DESolve BRS. Post\u2010procedural angiographic assessment indicated an in\u2010scaffold acute gain of 1.54\u2009\u00b1\u20090.44 mm, with a reduction in % diameter stenosis from 61.00\u2009\u00b1\u200911.29 to 12.69\u2009\u00b1\u20090.44. At 12 months, the device\u2010oriented composite endpoint had occurred in 3.0% (3\/100) of patients, with 1.0% (1\/100) experiencing scaffold thrombosis and myocardial infarction and 3.0% (3\/100) undergoing target lesion revascularization. There were no cardiac deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results through 12 months indicate that the DESolve BRS is a safe and effective treatment for coronary lesions, though larger, long\u2010term prospective studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.27550","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T04:14:48Z","timestamp":1520309688000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":21,"title":["A multicenter post\u2010marketing evaluation of the Elixir DESolve\n                    <sup>\u00ae<\/sup>\n                    Novolimus\u2010eluting bioresorbable coronary scaffold system: First results from the DESolve PMCF study"],"prefix":"10.1002","volume":"92","author":[{"given":"Holger","family":"Nef","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology University of Giessen, Medizinische Klinik I Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-7347","authenticated-orcid":false,"given":"Jens","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Deutsches Herzzentrum Muenchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3533","authenticated-orcid":false,"given":"Niklas","family":"Boeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of Giessen, Medizinische Klinik I Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-6956","authenticated-orcid":false,"given":"Oliver","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of Giessen, Medizinische Klinik I Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of Giessen, Medizinische Klinik I Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Eugen","family":"Hauptmann","sequence":"additional","affiliation":[{"name":"Krankenhaus der Barmherzigen Br\u00fcder Trier Trier Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Ospedale San Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Ospedale San Raffaele Milan 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