{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:49:40Z","timestamp":1778618980476,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the association of diabetes mellitus (DM) with clinical and angiographic characteristics and outcomes of patients with popliteal and infrapopliteal peripheral arterial disease (PAD) undergoing peripheral vascular intervention (PVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical features and outcomes in patients with DM and popliteal or infrapopliteal PAD undergoing PVI are not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the data from the laser in popliteal and infrapopliteal stenosis study, we retrospectively examined the association of diabetes with clinical and angiographic characteristics and risk adjusted short\u2010 and intermediate term outcomes (all cause death, major adverse events (MAE) [composite of death, ipsilateral major amputation, or repeat revascularization]) in patients with popliteal and infrapopliteal PAD undergoing PVI for critical limb ischemia treated either with laser\u2010assisted balloon angioplasty or balloon angioplasty alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 714 patients, 418 had DM (58.5%). Patients with DM were younger with higher prevalence of history of coronary artery disease, heart failure, end\u2010stage renal disease, and prior contralateral limb amputation compared to those without DM. At 5 years, mean event free survival for all cause mortality (39.9 vs. 45.5 months; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), MAE (29.3 vs. 36.8 months; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), ipsilateral major amputation (55.3 vs. 57.4 months; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and repeat revascularization (42.0 vs. 45.8 months; <jats:italic>P<\/jats:italic>\u2009=\u20090.03) were significantly lower in DM patients. On multivariate analysis, DM was associated with significantly higher all cause mortality (HR\u2009=\u20091.83, 95% CI 1.33\u20132.52), MAE (HR\u2009=\u20091.73, 95% CI 1.35\u20132.23), and ipsilateral major amputation (HR\u2009=\u20095.52, 95% CI 1.82\u201316.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with popliteal and infrapopliteal PAD undergoing PVI, DM was associated with higher mortality, major amputations and MAE that was independent of baseline comorbidities. Our data suggested the need for future studies evaluating existing and\/or novel therapies to improve the poor long\u2010term outcomes in diabetic patients with popliteal and infrapopliteal PAD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27571","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T11:48:41Z","timestamp":1521114521000},"page":"117-123","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term outcomes of patients with diabetes mellitus undergoing percutaneous intervention for popliteal and infrapopliteal peripheral arterial disease"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-0416","authenticated-orcid":false,"given":"Saroj","family":"Neupane","sequence":"first","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushruth","family":"Edla","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eesha","family":"Maidona","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Sweet","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Szpunar","sequence":"additional","affiliation":[{"name":"Medical Education, St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"LaLonde","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard S.","family":"Rosman","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Cardiology St John Hospital and Medical Center Detroit 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