{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:52:29Z","timestamp":1761562349424,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the target lesion failure (TLF) rate of the SYNERGY stent in all\u2010comers, multiethnic Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, most drug eluting stents deliver anti\u2010proliferative drugs from a durable polymer which is associated with a risk of late stent thrombosis. The novel everolimus\u2010eluting, platinum chromium SYNERGY stent is coated with a bioabsorbable abluminal polymer that resolves within 4 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, single center registry of consecutive patients treated with the SYNERGY stent between December 2012 and April 2015. The primary outcome was the incidence of TLF, defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization (TLR) at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 807 patients received the SYNERGY stent during the study period. One\u2010year clinical outcome data was available for 765 patients (94.8%) and were considered for statistical analysis. The mean age was 60.7\u2009\u00b1\u200910.8 years, and 83.4% were males. Patients with acute myocardial infarction consisted of 50.3% (ST\u2010segment elevation myocardial infarction: 23.0%, Non\u2010ST\u2010segment elevation myocardial infarction: 27.3%) of the study population. The treated lesions were complex (ACC\/AHA type B2\/C: 72.7%). The primary end point of TLF at 1 year was 5.8%. Rates of cardiac mortality, target vessel myocardial infarction, and TLR were 4.2, 1.0, and 1.3%, respectively, at 1 year. Predictors of the incidence and time to early TLF were female gender, Malay ethnicity, diabetes mellitus, acute myocardial infarction at presentation, a prior history of coronary artery bypass surgery and the presence of lesion calcification. The incidence of definite stent thrombosis was 0.4% at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this registry, the use of the SYNERGY stent was associated with low rates of TLF at 1 year.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27577","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T15:24:49Z","timestamp":1520436289000},"page":"1097-1103","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and predictors of target lesion failure in a multiethnic Asian population receiving the SYNERGY coronary stent: A prospective all\u2010comers registry"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-1198","authenticated-orcid":false,"given":"Rajiv","family":"Ananthakrishna","sequence":"first","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Kristanto","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew\u2010Pang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poay Huan","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-6030","authenticated-orcid":false,"given":"Edgar L.","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koo Hui","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian F.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huay Cheem","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-3098","authenticated-orcid":false,"given":"Joshua P.","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre 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