{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:34:19Z","timestamp":1791862459441,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008645","name":"Terumo Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the immediate and short term impact of right coronary artery (RCA) chronic total coronary occlusion (CTO) percutaneous coronary intervention (PCI) upon collateral donor vessel fractional flow reserve (FFR) and instantaneous wave\u2010free ratio (iFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>CTO PCI influences collateral donor vessel physiology, making the indication and\/or timing of donor vessel revascularization difficult to determine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In patients with RCA CTO, FFR, iFR, and collateral function index (FFR<jats:sub>coll<\/jats:sub>) were measured in LAD and LCx pre\u2010CTO PCI, immediately post and at 4 month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>34 patients underwent successful PCI. In the predominant donor vessel immediately post PCI, FFR, and FFR<jats:sub>coll<\/jats:sub> did not change (0.76\u2009\u00b1\u20090.12 to 0.75\u2009\u00b1\u20090.13, <jats:italic>P<\/jats:italic>\u2009=\u20090.267 and 0.31\u2009\u00b1\u20090.10 vs. 0.34\u2009\u00b1\u20090.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.078), but iFR increased significantly (0.86\u2009\u00b1\u20090.10 to 0.88\u2009\u00b1\u20090.10, <jats:italic>P<\/jats:italic>\u2009=\u20090.012). At follow\u2010up, there was a significant increase in predominant donor FFR and iFR (0.76\u2009\u00b1\u20090.12 to 0.79\u2009\u00b1\u20090.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.047 and 0.86\u2009\u00b1\u20090.10 to 0.90\u2009\u00b1\u20090.07, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), accompanied by a significant reduction in FFR<jats:sub>coll<\/jats:sub> (0.31\u2009\u00b1\u20090.10 to 0.18\u2009\u00b1\u20090.07 <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). These changes resulted in a reclassification of the predominant donor vessel from ischemic to nonischemic in 18% (FFR) and 25% (iFR) of the cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful recanalization of an RCA CTO resulted in a modest but statistically significant increase in the predominant donor vessel immediately post CTO PCI in the case of iFR and at 4\u2010month follow\u2010up for FFR and iFR compared to pre\u2010PCI with a concomitant reduction in collateral function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27587","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T07:15:05Z","timestamp":1521789305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The impact of coronary chronic total occlusion percutaneous coronary intervention upon donor vessel fractional flow reserve and instantaneous wave\u2010free ratio: Implications for physiology\u2010guided PCI in patients with CTO"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-5361","authenticated-orcid":false,"given":"Shah R.","family":"Mohdnazri","sequence":"first","affiliation":[{"name":"Department of Cardiology The Essex Cardiothoracic Centre Basildon United Kingdom"},{"name":"School of Medicine, Faculty of Medical Science Anglia Ruskin University, Cambridge and Chelmsford  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoris V.","family":"Karamasis","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Essex Cardiothoracic Centre Basildon United Kingdom"},{"name":"School of Medicine, Faculty of Medical Science Anglia Ruskin University, Cambridge and Chelmsford  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Al\u2010Janabi","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Essex Cardiothoracic Centre Basildon United Kingdom"},{"name":"School of Medicine, Faculty of Medical Science Anglia Ruskin University, Cambridge and Chelmsford  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Cook","sequence":"additional","affiliation":[{"name":"International Centre for Circulatory Health, National Heart and Lung Institue Imperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hampton\u2010Till","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical Science Anglia Ruskin University, Cambridge and Chelmsford  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical Science Anglia Ruskin University, Cambridge and Chelmsford  United 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