{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:44:02Z","timestamp":1751467442426,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated sex\u2010based and regional outcomes after contemporary percutaneous coronary intervention (PCI) with the Xience V stent in patients with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This patient level pooled analysis includes three multi\u2010center, prospective post\u2010market registries performed in the US, Japan, and China. A total of 1,938 patients treated with Xience V stents in the setting of AMI were enrolled. Compared to men, women had higher major adverse cardiac events (MACE) (14.1% vs. 9.8% <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, RR 1.4, 95% CI 1.1\u20131.4) and all\u2010cause mortality (10% vs. 6.2% <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, RR 1.61, 95% CI 1.14\u20132.27) at one year, without any significant difference in device specific outcomes of target vessel failure (TVF). US patients compared to the patients from China and Japan had increased MACE (female: 18% vs. 7.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.0012, male: 15.7% vs. 4.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Multivariable analysis demonstrated that major bleeding was the strongest predictor of MACE (OR 10.51, 95%CI 4.01\u201327.50, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), MI (OR 4.26, 95%CI 1.37\u201313.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.012), and all\u2010cause death (OR 5.3, 95%CI 2.32\u201312.13, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with AMI who underwent PCI with XIENCE DES have higher all\u2010cause mortality at one year in compared to men. Region based outcomes demonstrated increased MACE among US patients compared to the patients from China and Japan. After adjusting for differences in demographics, major bleeding, rather than female sex, predicted the higher observed all\u2010cause mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27622","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T09:36:39Z","timestamp":1525944999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex disparities in acute myocardial infarction care and outcomes"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-5932","authenticated-orcid":false,"given":"Burcu","family":"Gul","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Teikyo University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido","family":"Haimi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Simonton","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Wa","family":"Ying","sequence":"additional","affiliation":[{"name":"Abbott Vascular Santa Clara California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Buda","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Mehta","sequence":"additional","affiliation":[{"name":"Lumen Global and LATIN Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine New Haven Connecticut"},{"name":"Department of Cardiology St Bartholomew's Hospital London United Kingdom"},{"name":"William Harvey Research Institute and Queen Mary University of London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-7497","authenticated-orcid":false,"given":"Alexandra","family":"Lansky","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine New Haven Connecticut"},{"name":"Department of Cardiology St Bartholomew's Hospital London United Kingdom"},{"name":"William Harvey Research Institute and Queen Mary University of London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"unstructured":"World Health Organization (WHO). 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J Cardiol.2006;48:439\u2013475.","key":"e_1_2_8_8_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1093\/eurheartj\/ehr027"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1592\/phco.20.13.1034.35034"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/j.ijcard.2015.04.073"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1161\/CIRCULATIONAHA.116.025946"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1136\/openhrt-2014-000064"},{"unstructured":"XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post\u2010Approval Single\u2010Arm Study (XV CHINA 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