{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:36:22Z","timestamp":1764002182569,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify invasive hemodynamic parameters that correlate with infarction size in patients with ST\u2010elevation myocardial infarction (STEMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive hemodynamics obtained during primary percutaneous coronary intervention (PPCI) are predictive of mortality in STEMI, but which parameters correlate best with the size of the infarction are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center study of 405 adult patients with STEMI who had left ventricular end\u2010diastolic pressure (LVEDP) measured during PPCI. Size of infarction was estimated by peak troponin I level and ejection fraction (LVEF) determined by echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average (\u00b1SD) age was 61\u2009\u00b1\u200914 years, TIMI STEMI risk score was 3.5\u2009\u00b1\u20092.7 and Grace score was 157\u2009\u00b1\u200942. Hemodynamic parameters that correlated best with EF were LVEDP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.40), PP (<jats:italic>r<\/jats:italic>\u2009=\u20090.24), and SBP\/LVEDP ratio (<jats:italic>r<\/jats:italic>\u2009=\u20090.22) and with peak troponin were SBP\/LVEDP ratio (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.41), LVEDP (<jats:italic>r<\/jats:italic>\u2009=\u20090.31), and PP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.29). SBP\/LVEDP (AUC\u2009=\u20090.76) and SBP (AUC\u2009=\u20090.77) had a stronger association with in\u2010hospital mortality than did LVEDP (AUC\u2009=\u20090.66) or PP (AUC\u2009=\u20090.64). Door\u2010to\u2010balloon time did not affect the correlations between hemodynamic parameters and infarct size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this sample of 405 patients undergoing PPCI, SBP\/LVEDP ratio had the strongest correlation with peak troponin levels and LVEDP with EF, whereas SBP\/LVEDP and SBP had a strong association with in\u2010hospital mortality. These results suggest that measurement of LVEDP as well as SBP may help risk stratify patients during PPCI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27625","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T02:23:12Z","timestamp":1522030992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation of infarct size with invasive hemodynamics in patients with ST\u2010elevation myocardial infarction"],"prefix":"10.1002","volume":"92","author":[{"given":"Allie E.","family":"Goins","sequence":"first","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rayson","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina Chapel Hill North 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