{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:11Z","timestamp":1747147271102,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Narrowing of the coronary sinus (CS) has recently emerged as a new therapeutic option for the treatment of patients with chronic refractory angina pectoris. The results of the preclinical study presented here, evaluate the safety, feasibility, and efficacy of reducer implantation in a swine model with and without myocardial ischemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study included a safety\/feasibility arm, and a safety\/efficacy arm. In the safety\/feasibility arm, reducers were implanted in 26 mini swine; follow up of up to 6\u2009months included cardiac catheterization with CS angiogram, and histological evaluation of the stented segments of the CS. In the safety\/efficacy arm, eight swine with evidence of inducible myocardial ischemia were divided into reducer implantation group (<jats:italic>n<\/jats:italic>\u2009=\u20094) and a control group (<jats:italic>n<\/jats:italic>\u2009=\u20094). Follow\u2010up in this arm included 6\u2009weeks and 6\u2009months dobutamine stress echo and myocardial contrast echo to evaluate severity and extent of ischemia.<\/jats:p><jats:p>In the safety\/feasibility arm (<jats:italic>n<\/jats:italic>\u2009=\u200926), reducers were implanted with procedural success rate of 100% and with no short or long\u2010term complications. All CS reducers were found to be patent at the time of sacrifice. In the safety\/efficacy arm, all four animals with myocardial ischemia that underwent reducer implantation showed improvement in ischemia parameters at 6\u2009weeks and 6\u2009months follow\u2010up, with no mortality. Among the control group, no improvement in ischemia parameters was observed and three out of four animals died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Narrowing of the CS using percutaneous implantation of the reducer in swine is feasible, safe, and improves the extent and severity of ischemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27709","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T08:59:21Z","timestamp":1538297961000},"page":"1274-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Coronary sinus reducer for the treatment of chronic refractory angina pectoris\u2010results of the preclinical safety and feasibility study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-471X","authenticated-orcid":false,"given":"Maayan","family":"Konigstein","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sackler Faculty of Medicine, Tel\u2010Aviv Medical Center Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rona","family":"Shofti","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Research Authority Technion  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Neovasc, Inc.  Richmond British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sackler Faculty of Medicine, Tel\u2010Aviv Medical Center Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I11A209"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I10A196"},{"issue":"5","key":"e_1_2_7_4_1","first-page":"238","article-title":"Narrowing of the coronary sinus: A device\u2010based therapy for persistent angina pectoris","volume":"24","author":"Konigstein M","year":"2016","journal-title":"Cardiology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402556"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.061"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0862-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1956.02970350019005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(60)90313-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1963.tb07895.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960300008003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2706"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.115786"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002743"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.63040260007008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90637-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.3.695"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1361"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"20","article-title":"The development and rationale of pressure\u2010controlled intermittent coronary sinus occlusion\u2014A new approach to protect ischemic myocardium","volume":"96","author":"Mohl W","year":"1984","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90526-5"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.27709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.27709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.27709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:19:55Z","timestamp":1694801995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.27709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,30]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/ccd.27709"],"URL":"https:\/\/doi.org\/10.1002\/ccd.27709","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2018,9,30]]},"assertion":[{"value":"2017-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}