{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:41:44Z","timestamp":1762659704228,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adults with congenital heart disease (ACHD) are vulnerable to contrast\u2010induced acute kidney injury (CI\u2010AKI) after cardiac catheterization. The aim of this study was to identify risk factors for clinically significant CI\u2010AKI and evaluate the predictive value of contrast volume to estimated glomerular filtration rate ratio (V\/eGFR) for the risk of CI\u2010AKI following catheterization in the ACHD population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ACHD patients who underwent catheterization at Boston Children's hospital between 1\/2011 and 1\/2017 were retrospectively analyzed. CI\u2010AKI was defined as an increase in serum creatinine \u22650.3 mg\/dL within 48 hr or \u22651.5 times baseline within 7 days of procedure. Controls without CI\u2010AKI were matched for calendar year of catheterization with cases using a 3:1 ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 453 catheterizations meeting inclusion criteria, 27 catheterizations (5.9%) were complicated by CI\u2010AKI, with dialysis being used to manage renal dysfunction in five of these events. Older age, male gender, admission prior to catheterization, and V\/eGFR ratio were found to be related to risk of CI\u2010AKI. Patients with a V\/eGFR \u2265 2.6 had a significantly higher risk of CI\u2010AKI (OR = 6.4; 95% CI = 2.0\u201320.4; <jats:italic>P<\/jats:italic> = 0.002). Survival at 3 years post\u2010catheterization, was significantly shorter for CI\u2010AKI cases compared to controls (49% versus 97%; <jats:italic>P<\/jats:italic> &lt; 0.001) even in those with return to baseline renal function prior to discharge (60% versus 97%, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In ACHD patients undergoing cardiac catheterization, a higher V\/eGFR ratio is a strong predictor of clinically significant CI\u2010AKI. Development of CI\u2010AKI is a poor prognostic indicator and is associated with decreased survival in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27798","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T07:38:17Z","timestamp":1536478697000},"page":"1301-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Contrast volume to estimated glomerular filtration rate ratio for prediction of contrast\u2010induced acute kidney injury after cardiac catheterization in adults with congenital heart disease"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-4478","authenticated-orcid":false,"given":"Laura","family":"Gellis","sequence":"first","affiliation":[{"name":"Boston Children's Hospital  Boston 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