{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:16Z","timestamp":1747147276718,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the effectiveness and safety of self\u2010expandable, sirolimus\u2010eluting Stentys stents (SES) and second\u2010generation drug\u2010eluting stents (DES\u2010II) for the treatment of the unprotected left main (ULM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>SES may provide a valuable option to treat distal ULM, particularly when significant caliber gaps with side branches are observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the multicenter SPARTA (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>: NCT02784405) and FAILS2 registries were included. Propensity\u2010score with matching was performed to account for the lack of randomization. Primary end\u2010point was the rate of major adverse cardiovascular events (MACE, a composite of all cause death, myocardial infarction, target lesion revascularization [TLR], unstable angina and definite stent thrombosis [ST]). Single components of MACE were the secondary end\u2010points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 151 patients treated with SES and 1270 with DES\u2010II were included; no differences in MACE rate at 250\u2009days were observed (9.8% vs. 11.5%, <jats:italic>P<\/jats:italic> = 0.54). After propensity score with matching, 129 patients treated with SES and 258 with DES\u2010II, of which about a third of female gender, were compared. After a follow\u2010up of 250\u2009days, MACE rate did not differ between the two groups (9.9% vs. 8.5%, <jats:italic>P<\/jats:italic> = 0.66), as well as the rate of ULM TLR (1.6% vs. 3.1%, <jats:italic>P<\/jats:italic> = 0.36) and definite ST (0.8% vs. 1.2%, <jats:italic>P<\/jats:italic> = 0.78). These results were consistent also when controlling for the treatment with provisional vs. 2\u2010stents strategies for the ULM bifurcation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SES use for ULM treatment was associated with a similar MACE rate compared to DES\u2010II at an intermediate\u2010term follow\u2010up. SES might represent a potential option in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27809","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T04:15:38Z","timestamp":1539058538000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010expandable sirolimus\u2010eluting stents compared to second\u2010generation drug\u2010eluting stents for the treatment of the left main: A propensity score analysis from the SPARTA and the FAILS\u20102 registries"],"prefix":"10.1002","volume":"93","author":[{"given":"Antonio","family":"Montefusco","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Division of Cardiology AOU Citt\u00e0 della Salute e della Scienza, University of Turin  Turin 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