{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:05:34Z","timestamp":1773061534966,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Use of a Bioresorbable Scaffolds (BRS) either in clinical practice or in the setting of an acute myocardial infarction (MI) is controversial. Despite an overall high rate of thrombosis, vascular healing response following BRS implantation tend to superiority as compared to metallic drug\u2010eluting stent in ST\u2010segment elevation myocardial infarction (STEMI) patients.<\/jats:p><jats:p>We sought to compare the in\u2010stent\/scaffold vasomotion between metallic BRS and sirolimus eluting stent (SES) at 12\u2010month angiographic follow\u2010up in the setting of patients with STEMI treated by primary PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>This is an investigator\u2010driven, prospective, multicenter, randomized, single blind, two\u2010arm, controlled trial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> number: NCT03234348). This trial will randomize ~148 patients 1:1 to SES or BRS. Primary end\u2010point is the in\u2010stent\/scaffold change in mean lumen diameter after nitroglycerin administration at 12\u2010month angiographic follow\u2010up. Besides, patient\u2010oriented combined endpoint of all\u2010cause death, any MI, and any revascularization, together with scaffold\/stent thrombosis rate and device\u2010oriented endpoint of cardiac death, target vessel (TV)\u2010MI and TVR at 1 year will be also evaluated. Clinical follow\u2010up will be scheduled yearly up to 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This trial will shed light on the vascular vasomotion following BRS implantation in the complex scenario of STEMI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.27825","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T07:37:59Z","timestamp":1536478679000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MAGnesium\u2010based bioresorbable scaffold and vasomotor function in patients with acute ST segment elevation myocardial infarction: The MAGSTEMI trial: Rationale and design"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-1435","authenticated-orcid":false,"given":"Salvatore","family":"Brugaletta","sequence":"first","affiliation":[{"name":"Department of Cardiology, Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Cequier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital de Bellvitge  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital La Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Alvaro Cunqueiro  Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Roman\u00ed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital San Pedro de Alc\u00e1ntara  C\u00e1ceres 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